Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse

Satoshi Seino, Yurie Tanaka, Taro Honma, Miyuki Yanaka, Kenta Sato, Nahoko Shinohara, Junya Ito, Tsuyoshi Tsuduki, Kiyotaka Nakagawa, Teruo Miyazawa, Ikuo Ikeda

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Various factors have been reported to influence lipid metabolism and cause metabolic syndrome. However, the influence of allergy on the liver that plays important role of lipid metabolism has not been clarified. The aim of this study was to examine the influence of allergy on lipid metabolism of liver. A model of atopic dermatitis was developed in the NC/Nga mouse using picryl chloride to induce allergy. Lipid metabolism parameters were measured and the mechanism of changes in these parameters was examined using DNA microarray analysis and quantitative reverse transcriptase PCR. Triacylglycerol accumulation was promoted in the liver in the mouse atopic dermatitis model despite reductions in food intake, body weight gain, and serum glucose. As this mechanism, it was thought that atopic dermatitis caused the suppression of fatty acid β-oxidation. These results suggest that atopic dermatitis causes lipid accumulation in the liver.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume50
Issue number2
DOIs
Publication statusPublished - 2012 Mar

Keywords

  • Allergy
  • DNA microarray
  • Lipid metabolism
  • Liver
  • NC/Nga

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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