Atomic force microscope studies on condensation of plasmid DNA with functionalized fullerenes

Hiroyuki Isobe, Sho Sugiyama, Ken Ichi Fukui, Yasuhiro Iwasawa, Eiichi Nakamura

    Research output: Contribution to journalArticlepeer-review

    54 Citations (Scopus)

    Abstract

    DNA condensation by a fullerene vector has been imaged at the molecular level by atomic force microscopy (AFM); analysis of a mixture of plasmid DNA and DNA-binding fullerene with the aid of this carbonaceous vector provided the first information on the mechanism of transfection. The picture shows AFM images of pBR322 DNA in the absence of (left) and partially condensed by the fullerene (right).

    Original languageEnglish
    Pages (from-to)3364-3367
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume40
    Issue number18
    DOIs
    Publication statusPublished - 2001 Sep 17

    Keywords

    • DNA recognition
    • Fullerenes
    • Polycations
    • Scanning probe microscopy
    • Transfection

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)

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