ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis

Kaoru O. Yoshiyama, Junya Kobayashi, Nobuo Ogita, Minako Ueda, Seisuke Kimura, Hisaji Maki, Masaaki Umeda

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

Arabidopsis SOG1 (suppressor of gamma response 1) is a plant-specific transcription factor that governs the DNA damage response. Here we report that SOG1 is phosphorylated in response to DNA damage, and that this phosphorylation is mediated by the sensor kinase ataxia telangiectasia mutated (ATM). We show that SOG1 phosphorylation is crucial for the response to DNA damage, including transcriptional induction of downstream genes, transient arrest of cell division and programmed cell death. Although the amino-acid sequences of SOG1 and the mammalian tumour suppressor p53 show no similarity, this study demonstrates that ATM-mediated phosphorylation of a transcription factor has a pivotal role in the DNA damage response in both plants and mammals.

Original languageEnglish
Pages (from-to)817-822
Number of pages6
JournalEMBO Reports
Volume14
Issue number9
DOIs
Publication statusPublished - 2013 Sep
Externally publishedYes

Keywords

  • Arabidopsis
  • ATM
  • DNA damage
  • Phosphorylation
  • SOG1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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