Atg11 directs autophagosome cargoes to the PAS along act in cables

Iryna Monastyrska, Takahiro Shintani, Daniel J. Klionsky, Fulvio Reggiori

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)

    Abstract

    For more than 40 years, autophagy has been almost exclusively studied as a cellular response that allows adaptation to starvation situations. In nutrient-deprived conditions, cytoplasmic components and organelles are randomly sequestered into double-membrane vesicles called autophagosomes, creating the notion that this pathway is a nonselective process (reviewed in refs 1 and 2). Recent results, however, have demonstrated that under certain circumstances, cargoes such as protein complexes, organelles and bacteria can be selectively and exclusively incorporated into double-membrane vesicles. We have recently shown that actin plays an essential role in two selective types of autophagy in the yeast Saccharomyces cerevisiae, the cytoplasm to vacuole targeting (Cvt) pathway and pexophagy, raising the possibility that the structures formed by polymers of this protein helps autophagosomes in recognizing the cargoes that must be delivered to the vacuole. In this addendum, we discuss the possible central role of Atg11 as a molecule connecting cargoes, actin and pre-autophagosomal structure (PAS) elements.

    Original languageEnglish
    Pages (from-to)119-121
    Number of pages3
    JournalAutophagy
    Volume2
    Issue number2
    DOIs
    Publication statusPublished - 2006

    Keywords

    • Autophagy
    • Cytoplasm to vacuole targeting
    • Myosin
    • Pexophagy
    • Yeast

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology

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