Abstract
A resin-supported N-terminal prolyl peptide having a β-turn motif and a polyleucine tether has been developed for the organocatalytic asymmetric transfer hydrogenation under aqueous conditions. Polyleucine accelerated the reaction in a highly enantioselective manner by providing a hydrophobic microenvironment around the prolyl residue. The investigation of catalyst structures indicates that the l-form of polyleucine is essential for both reaction efficiency and enantioselectivity.
Original language | English |
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Pages (from-to) | 461-466 |
Number of pages | 6 |
Journal | Tetrahedron Asymmetry |
Volume | 20 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2009 Mar 11 |
ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry