Asymmetric synthesis with a chiral catalyst generated from asymmetric autocatalysis

Itaru Sato, Hiroki Urabe, Shinji Ishii, Shigehisa Tanji, Kenso Soai

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Equation Presented A new and efficient one-pot system of asymmetric catalysis is presented in which a chiral catalyst (5-pyrimidyl alkanol) self-improves its ee by asymmetric autocatalysis and then acts as a highly enantioselective chiral catalyst for other asymmetric synthesis (addition of dialkylzincs to aldehydes) to provide products (sec-alcohols) with very high ee (up to 99%).

Original languageEnglish
Pages (from-to)3851-3853
Number of pages3
JournalOrganic letters
Volume3
Issue number24
DOIs
Publication statusPublished - 2001 Nov 29

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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