Asymmetric synthesis utilizing circularly polarized light mediated by the photoequilibrium of chiral olefins in conjunction with asymmetric autocatalysis

Itaru Sato, Rie Sugie, Yohei Matsueda, Yuri Furumura, Kenso Soai

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The light touch: Asymmetric photoequilibrium and autocatalysis act as sources of homochirality in a highly enantioselective preparation of chiral alcohols (see scheme). This process is initiated by left- and right-circularly polarized light (CPL) and exploits the resulting photoequilibrium between chiral olefin substrates to yield 2-alkynyl-5-pyrimidyl alkanols.

Original languageEnglish
Pages (from-to)4490-4492
Number of pages3
JournalAngewandte Chemie - International Edition
Volume43
Issue number34
DOIs
Publication statusPublished - 2004 Aug 27

Keywords

  • Alkenes
  • Asymmetric amplification
  • Asymmetric catalysis
  • Autocatalysis
  • Chirality

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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