Abstract
The reaction of the chiral lithium amide 4 with the dienoate 5a provides regio- and stereo-selectively the β-amino ester 8 in essentially quantitative yield with >99% diastereoisomeric excess, which can be converted upon sequential treatment with LiNPri2-B(OMe) 3-MeCHO to the key intermediate 6 for the β-lactam 7 having the correct absolute configuration.
Original language | English |
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Pages (from-to) | 1660-1662 |
Number of pages | 3 |
Journal | Journal of the Chemical Society, Chemical Communications |
Issue number | 21 |
DOIs | |
Publication status | Published - 1993 Dec 1 |
ASJC Scopus subject areas
- Molecular Medicine