The reaction of the chiral lithium amide 4 with the dienoate 5a provides regio- and stereo-selectively the β-amino ester 8 in essentially quantitative yield with >99% diastereoisomeric excess, which can be converted upon sequential treatment with LiNPri2-B(OMe) 3-MeCHO to the key intermediate 6 for the β-lactam 7 having the correct absolute configuration.
|Number of pages||3|
|Journal||Journal of the Chemical Society, Chemical Communications|
|Publication status||Published - 1993 Dec 1|
ASJC Scopus subject areas
- Molecular Medicine