Asymmetric synthesis of the β-lactam framework via a three-component coupling reaction

Naoki Asao, Naofumi Tsukada, Yoshinori Yamamoto

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    The reaction of the chiral lithium amide 4 with the dienoate 5a provides regio- and stereo-selectively the β-amino ester 8 in essentially quantitative yield with >99% diastereoisomeric excess, which can be converted upon sequential treatment with LiNPri2-B(OMe) 3-MeCHO to the key intermediate 6 for the β-lactam 7 having the correct absolute configuration.

    Original languageEnglish
    Pages (from-to)1660-1662
    Number of pages3
    JournalJournal of the Chemical Society, Chemical Communications
    Issue number21
    DOIs
    Publication statusPublished - 1993 Dec 1

    ASJC Scopus subject areas

    • Molecular Medicine

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