Asymmetric Synthesis of Functionalized 9-Methyldecalins Using a Diphenylprolinol-Silyl-Ether-Mediated Domino Michael/Aldol Reaction

Yujiro Hayashi, Hugo A. Salazar, Seitaro Koshino

Research output: Contribution to journalArticlepeer-review

Abstract

Substituted 9-methyldecalin derivatives containing an all carbon quaternary chiral center were synthesized with excellent enantioselectivity via an organocatalyst-mediated domino reaction. The first reaction is a diphenylprolinol silyl ether-mediated Michael reaction, and the second reaction is an intramolecular aldol reaction. The enantiomerically pure catalyst is involved in both reactions.

Original languageEnglish
Pages (from-to)6654-6658
Number of pages5
JournalOrganic letters
Volume23
Issue number17
DOIs
Publication statusPublished - 2021 Sep 3

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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