Asymmetric synthesis of an organic compound with high enantiomeric excess induced by inorganic ionic sodium chlorate

Itaru Sato, Kousuke Kadowaki, Kenso Soai

Research output: Contribution to journalArticlepeer-review

127 Citations (Scopus)

Abstract

Morphologically chiral crystals of sodium chlorate induce highly enantioselective synthesis. Thus the addition of diisopropylzinc to 2-(tert- butylethynyl)pyrimidine-5-carbaldehyde in the presence of d- and l-NaClO3 gives the (S)- and (R)-alkanol, respectively, in high yields and with high ee values.

Original languageEnglish
Pages (from-to)1510-1512
Number of pages3
JournalAngewandte Chemie - International Edition
Volume39
Issue number8
DOIs
Publication statusPublished - 2000 Apr 17

Keywords

  • Asymmetric synthesis
  • Autocatalysis
  • Molecular recognition
  • Surface chemistry
  • Zinc

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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