Abstract
Anti Mannich, try this! A direct asymmetric Mannich reaction catalyzed by a diarylprolinol silyl ether was developed to afford the anti-Mannich product with excellent enantioselectivity. Imines derived from both aliphatic and aromatic aldehydes were successfully used to obtain the synthetically important β-amino aldehydes (see scheme; Ts=tosyl). The reaction can also be performed in the presence of water.
Original language | English |
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Pages (from-to) | 8273-8276 |
Number of pages | 4 |
Journal | Chemistry - A European Journal |
Volume | 17 |
Issue number | 30 |
DOIs | |
Publication status | Published - 2011 Jul 18 |
Externally published | Yes |
Keywords
- Mannich reaction
- asymmetric synthesis
- domino reactions
- enantioselectivity
- organocatalysis
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry