Asymmetric mannich reaction of α-keto imines catalyzed by diarylprolinol silyl ether

Yujiro Hayashi, Daisuke Sakamoto, Hiroki Shomura, Daisuke Hashizume

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Synthetic methods: An asymmetric catalytic, desulfonylative Mannich reaction of α-keto imines with aldehydes, as catalyzed by diarylprolinol silyl ether 1, was developed. It gave the Mannich product in good yield with excellent anti and enantioselectivity (see scheme; Boc=tert-butoxycarbonyl, TMS=trimethylsilyl).

Original languageEnglish
Pages (from-to)7678-7681
Number of pages4
JournalChemistry - A European Journal
Volume19
Issue number24
DOIs
Publication statusPublished - 2013 Jun 10

Keywords

  • domino reactions
  • enantioselectivity
  • one-pot reaction
  • organocatalysis
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

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