Abstract
Optically active 1,2-bis(alkylmethylphosphino)ethanes and bis(alkylmethylphosphino)methanes are unique diphosphine ligands combining the simple molecular structure and P-stereogenic asymmetric environment. This work shows that these ligands exhibit excellent enantioselectivity in rhodium-catalyzed asymmetric hydrogenation of α,β-unsaturated phosphonic acid derivatives. The enantioselective hydrogenation mechanism elucidated by NMR study is also described.
| Original language | English |
|---|---|
| Pages (from-to) | 5385-5390 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 101 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2004 Apr 13 |
ASJC Scopus subject areas
- General
Fingerprint Dive into the research topics of 'Asymmetric hydrogenation of α,β-unsaturated phosphonates with Rh-BisP* and Rh-MiniPHOS catalysts: Scope and mechanism of the reaction'. Together they form a unique fingerprint.
Cite this
Gridnev, I. D., Yasutake, M., Imamoto, T., & Beletskaya, I. P. (2004). Asymmetric hydrogenation of α,β-unsaturated phosphonates with Rh-BisP* and Rh-MiniPHOS catalysts: Scope and mechanism of the reaction. Proceedings of the National Academy of Sciences of the United States of America, 101(15), 5385-5390. https://doi.org/10.1073/pnas.0306993101