TY - JOUR
T1 - Asymmetric hydrogenation of α,β-unsaturated phosphonates with Rh-BisP* and Rh-MiniPHOS catalysts
T2 - Scope and mechanism of the reaction
AU - Gridnev, Ilya D.
AU - Yasutake, Masaya
AU - Imamoto, Tsuneo
AU - Beletskaya, Irina P.
PY - 2004/4/13
Y1 - 2004/4/13
N2 - Optically active 1,2-bis(alkylmethylphosphino)ethanes and bis(alkylmethylphosphino)methanes are unique diphosphine ligands combining the simple molecular structure and P-stereogenic asymmetric environment. This work shows that these ligands exhibit excellent enantioselectivity in rhodium-catalyzed asymmetric hydrogenation of α,β-unsaturated phosphonic acid derivatives. The enantioselective hydrogenation mechanism elucidated by NMR study is also described.
AB - Optically active 1,2-bis(alkylmethylphosphino)ethanes and bis(alkylmethylphosphino)methanes are unique diphosphine ligands combining the simple molecular structure and P-stereogenic asymmetric environment. This work shows that these ligands exhibit excellent enantioselectivity in rhodium-catalyzed asymmetric hydrogenation of α,β-unsaturated phosphonic acid derivatives. The enantioselective hydrogenation mechanism elucidated by NMR study is also described.
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U2 - 10.1073/pnas.0306993101
DO - 10.1073/pnas.0306993101
M3 - Article
C2 - 15024119
AN - SCOPUS:1842782788
VL - 101
SP - 5385
EP - 5390
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 15
ER -