Asymmetric hydrogenation of α,β-unsaturated phosphonates with Rh-BisP* and Rh-MiniPHOS catalysts: Scope and mechanism of the reaction

Ilya D. Gridnev, Masaya Yasutake, Tsuneo Imamoto, Irina P. Beletskaya

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Optically active 1,2-bis(alkylmethylphosphino)ethanes and bis(alkylmethylphosphino)methanes are unique diphosphine ligands combining the simple molecular structure and P-stereogenic asymmetric environment. This work shows that these ligands exhibit excellent enantioselectivity in rhodium-catalyzed asymmetric hydrogenation of α,β-unsaturated phosphonic acid derivatives. The enantioselective hydrogenation mechanism elucidated by NMR study is also described.

Original languageEnglish
Pages (from-to)5385-5390
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number15
DOIs
Publication statusPublished - 2004 Apr 13

ASJC Scopus subject areas

  • General

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