@article{dc47add5b3504c52a1458a1ed2fb37e9,
title = "Asymmetric Hydroacylation Involving Alkene Isomerization for the Construction of C3-Chirogenic Center",
abstract = "A new transformation pattern for enantioselective intramolecular hydroacylation has been developed involving an alkene isomerization strategy. Proceeding through a five-membered rhodacycle intermediate, 3-enals were converted to C3- or C3,C5-chirogenic cyclopentanones with satisfactory yields, diastereoselectivities, and enantioselectivities. A catalytic cycle has been theoretically calculated and the origin of the stereoselection is rationally explained.",
keywords = "alkene isomerization, cycloketones, hydroacylation, rhodacycle, β-H elimination",
author = "Chong Liu and Jing Yuan and Zhenfeng Zhang and Gridnev, {Ilya D.} and Wanbin Zhang",
note = "Funding Information: This work was supported by National Key R&D Program of China (No. 2018YFE0126800), National Natural Science Foundation of China (Nos. 21620102003, 21831005, 91856106, 21991112, 22071150), and Shanghai Municipal Education Commission (No. 201701070002E00030). We thank the Instrumental Analysis Center of Shanghai Jiao Tong University. We acknowledge the generous gifts of the P-chirogenic bisphosphine ligands from Nippon Chemical Industrial Co. Ltd. Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH",
year = "2021",
month = apr,
day = "12",
doi = "10.1002/anie.202017190",
language = "English",
volume = "60",
pages = "8997--9002",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "16",
}