Asymmetric formal [3 + 2] cycloaddition reaction of succinaldehyde via diarylprolinol-mediated domino aldol-acetalization reaction for the construction of tetrahydrofuran

Yujiro Hayashi, Kentaro Nishino, Itaru Sato

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Highly enantioselective synthesis of tetrahydrofurans was accomplished via a formal [3 + 2] cycloaddition reaction of succinaldehyde, which acts as a three-carbon unit. The reaction consists of the domino reaction of the diarylprolinol-mediated aldol reaction of succinaldehyde followed by an intramolecular acetalization reaction.

Original languageEnglish
Pages (from-to)1294-1296
Number of pages3
JournalChemistry Letters
Volume42
Issue number10
DOIs
Publication statusPublished - 2013 Oct 16

ASJC Scopus subject areas

  • Chemistry(all)

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