Asymmetric direct Mannich reaction catalyzed by chiral Brønsted acid via activation of enecarbamate as an aliphatic imine alternative

Masahiro Terada, Hiroyasu Tanaka, Keiichi Sorimachi

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

An enantioselective direct Mannich reaction of acetyl-acetone with enecarbamates via protonation by a chiral monophoshoric acid catalyst is achieved, demonstrating the utility of in situ generation of unstable aliphatic imines.

Original languageEnglish
Pages (from-to)1661-1664
Number of pages4
JournalSynlett
Issue number11
DOIs
Publication statusPublished - 2008 Jul 1

Keywords

  • Asymmetric catalysis
  • Imines
  • Isomerizations
  • Mannich reaction
  • Organocatalysis

ASJC Scopus subject areas

  • Organic Chemistry

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