Abstract
(Chemical Equation Presented) Water, water, everywhere: The title reaction predominantly affords the exo isomer with excellent enantioselectivity (see scheme; TMS=trimethylsilyl). The synthesis can be carried out without organic solvents and provides the products by distillation. Water increases the rate and enantioselectivity of the reaction.
Original language | English |
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Pages (from-to) | 6634-6637 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 47 |
Issue number | 35 |
DOIs | |
Publication status | Published - 2008 Aug 18 |
Externally published | Yes |
Keywords
- Asymmetric synthesis
- Cycloaddition
- Enantioselectivity
- Organocatalysis
- Water chemistry
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)