Abstract
The chiral titanium complex-catalyzed ene-type reaction with fluoral is shown to serve as an efficient route for the asymmetric synthesis of CF3-substituted compounds of biological and synthetic importance in extremely high enantiomeric excesses (>95% ee). The ene reactivity of trihaloacetaldehyde including fluoral is estimated in terms of the balance of LUMO energy level vs. electron density on the carbonyl carbon.
Original language | English |
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Pages (from-to) | 7591-7594 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 34 |
Issue number | 47 |
DOIs | |
Publication status | Published - 1993 Nov 19 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry