Asymmetric catalysis of carbonyl-ene and aldol reactions with fluoral by chiral binaphthol-derived titanium complex

Koichi Mikami, Tomoko Yajima, Tsuyoshi Takasaki, Satoru Matsukawa, Masahiro Terada, Tadafumi Uchimaru, Masamichi Maruta

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

The chiral titanium complex-catalyzed ene-type reaction and the Mukaiyama aldol reaction with fluoral are shown to serve as an efficient route to the enantiosclective and diastereoselective synthesis of CF3-substituted components of biological and synthetic importance.

Original languageEnglish
Pages (from-to)85-98
Number of pages14
JournalTetrahedron
Volume52
Issue number1
DOIs
Publication statusPublished - 1996 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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