Asymmetric catalysis by chiral titanium perchlorate for carbonyl-ene cyclization

Koichi Mikami, Masahiro Terada, Eiji Sawa, Takeshi Nakai

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The chiral binaphthol-derived titanium perchlorate is shown to serve efficiently as an asymmetric catalyst for the ene cyclization of type I and II involving α-alkoxy aldehyde as an internal enophile to afford the 6- and 7-membered cyclic ethers in high enantiomeric purity.

Original languageEnglish
Pages (from-to)6571-6574
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number45
DOIs
Publication statusPublished - 1991 Nov 4
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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