Asymmetric catalysis by chiral titanium perchlorate for carbonyl-ene cyclization

Koichi Mikami, Eiji Sawa, Masahiro Terada

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


The chiral binaphthol-derived titanium perchlorate (or triflate) is shown to serve efficiently as an asymmetric catalyst for the ene cyclization of type {3,4exo,exo} and {2,4exo′,exo} involving α-alkoxy aldehyde as an internal enophile to afford the 6- and 7- membered cyclic ethers in high enantiomeric purity.

Original languageEnglish
Pages (from-to)1403-1412
Number of pages10
JournalTetrahedron: Asymmetry
Issue number12
Publication statusPublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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