Asymmetric aldol reaction of glyoxal catalyzed by diarylprolinol

Yujiro Hayashi, Masahiro Kojima

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

All selection should be this- eeasy: The direct asymmetric aldol reaction of commercial aqueous glyoxal is catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a β-formyl-β-hydroxy-α-substituted aldehyde in good yield with excellent anti selectivity and excellent enantioselectivity.

Original languageEnglish
Pages (from-to)2883-2885
Number of pages3
JournalChemCatChem
Volume5
Issue number10
DOIs
Publication statusPublished - 2013 Oct

Keywords

  • Aldol reaction
  • Asymmetric synthesis
  • Enantioselectivity
  • Glyoxal
  • Organocatalysis

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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