Asymmetric aldol reaction of formaldehyde catalyzed by diarylprolinol

Yusuke Yasui, Meryem Benohoud, Itaru Sato, Yujiro Hayashi

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The asymmetric cross-aldol reaction of formaldehyde with aldehyde pronucleophiles, catalyzed by trifluoromethyl-substituted diarylprolinol 1, was accomplished to directly afford β-hydroxymethyl-substituted aldehydes in good yield with excellent enantioselectivity.

Original languageEnglish
Pages (from-to)556-558
Number of pages3
JournalChemistry Letters
Volume43
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

ASJC Scopus subject areas

  • Chemistry(all)

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