Asymmetric Aldol Reaction of α,α-Disubstituted Acetaldehydes Catalyzed by Diphenylprolinol Silyl Ether for the Construction of Quaternary Stereogenic Centers

Yujiro Hayashi, Hiroki Shomura, Qianqian Xu, Martin James Lear, Itaru Sato

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The asymmetric cross-aldol reaction of α,α-disubstituted acetaldehydes with commercial ethyl glyoxylate polymer was successfully catalyzed by diphenylprolinol silyl ether 3 to generate all-carbon quaternary stereogenic centers with good enantioselectivity. Diphenylprolinol silyl ether is an effective organocatalyst in the asymmetric cross-aldol reaction of α,α-disubstituted acetaldehydes with commercial ethyl glyoxylate polymer to generate all-carbon quaternary stereogenic centers with good enantioselectivity.

Original languageEnglish
Pages (from-to)4316-4319
Number of pages4
JournalEuropean Journal of Organic Chemistry
Volume2015
Issue number20
DOIs
Publication statusPublished - 2015 Jul 1

Keywords

  • Aldol reactions
  • Asymmetric synthesis
  • Organocatalysis
  • Quaternary stereogenic center

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Asymmetric Aldol Reaction of α,α-Disubstituted Acetaldehydes Catalyzed by Diphenylprolinol Silyl Ether for the Construction of Quaternary Stereogenic Centers'. Together they form a unique fingerprint.

  • Cite this