Asymmetric 1,4-addition of organosiloxanes to α,β-unsaturated carbonyl compounds catalyzed by a chiral rhodium complex

Shuichi Oi, Akio Taira, Yoshio Honma, Yoshio Inoue

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)

Abstract

(Matrix presented) Highly enantioselective 1,4-addition of organosiloxanes to α,β-unsaturated carbonyl compounds was found to be catalyzed by a chiral rhodium complex generated from [Rh(cod)(MeCN)2]BF4 and (S)-BINAP. Both (E)- and (Z)-1-alkenyl groups as well as aryl groups can be introduced enantioselectively into the β-position of a variety of ketones, esters, and amides.

Original languageEnglish
Pages (from-to)97-99
Number of pages3
JournalOrganic letters
Volume5
Issue number1
DOIs
Publication statusPublished - 2003 Jan 9

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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