(Matrix presented) Highly enantioselective 1,4-addition of organosiloxanes to α,β-unsaturated carbonyl compounds was found to be catalyzed by a chiral rhodium complex generated from [Rh(cod)(MeCN)2]BF4 and (S)-BINAP. Both (E)- and (Z)-1-alkenyl groups as well as aryl groups can be introduced enantioselectively into the β-position of a variety of ketones, esters, and amides.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry