Astrocyte growth enhanced by culture supernatant of a cloned rat thymic myoid cell

Aiko Tada-Kikuchi, Isao Kamo, Tsunetoshi Itoh, Ikuya Nonaka

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A conditioned medium (CM) from a cloned rat thymic myoid cell (IT-45R92) was used to investigate a possible relationship between the thymus and brain. CM stimulated the DNA synthesis of the cultured perinatal rat brain cells and spleen myelo-lymphoid cells but not that of the other types of cells including dorsal root ganglia, spinal cord, heart muscle, skeletal muscle, kidney, liver, skin and thymic fibroblasts. CM appeared to stimulate glioblasts to differentiate into mature astrocytes that have a characteristic intracellular fibrous structure and a glial fibrillary acidic protein. These results indicated that thymic myoid cells release (a) 'cytokine(s)' for the astrocytes and myelo-lymphoid cells, similar to a 'lymphokine' (glia cell stimulating factor, GSF) produced by murine and human lymphocytes stimulated with mitogens.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalBrain research
Volume348
Issue number2
DOIs
Publication statusPublished - 1985 Dec 2

Keywords

  • astrocyte
  • cytokine
  • differentiation
  • myelo-lymphoid cell
  • proliferation
  • thymic myoid cell

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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