Associations between prenatal exposure to volatile organic compounds and neurodevelopment in 12-month-old children: The Japan Environment and Children's Study (JECS)

the Japan Environment and Children's Study (JECS) Group

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Abstract

In recent years, there has been an increase in the number of problems associated with neurodevelopmental disorders in children, and there has been a growing interest in the relationship between environmental chemicals and children's health. The objective of this study was to examine whether an association exists between occupational or environmental prenatal maternal exposure to volatile organic compounds and the risk of neurodevelopmental disorders in children using Japanese translations of the Ages & Stages Questionnaires, Third Edition (J-ASQ-3). An increase in the risk of neurodevelopmental delay in 12-month-old children associated with maternal exposure to formalin or formaldehyde was identified in terms of problem-solving (odds ratio (OR): 1.76, 95% confidence interval (CI): 0.99–3.12) and personal-social skills (OR: 3.32, 95% CI: 1.46–7.55). It is not clear whether or not this tendency is reversible, and whether it is observed past 12 months of age. Further research and a preventive approach are needed.

Original languageEnglish
Article number148643
JournalScience of the Total Environment
Volume794
DOIs
Publication statusPublished - 2021 Nov 10

Keywords

  • Ages & Stages questionnaire
  • Cohort study
  • Formalin/formaldehyde
  • Neurodevelopmental disorder
  • Prenatal exposure

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

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