Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population

Yoshiko Tamura; Yuji Sakasegawa; Kazuya Omi; Hitaru Kishida; Takashi Asada; Hideo Kimura; Katsushi Tokunaga; Naomi S. Hachiya; Kiyotoshi Kaneko; Hirohiko Hohjoh

doi:10.1016/j.neulet.2004.12.056

Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population

Yoshiko Tamura, Yuji Sakasegawa, Kazuya Omi, Hitaru Kishida, Takashi Asada, Hideo Kimura, Katsushi Tokunaga, Naomi S. Hachiya, Kiyotoshi Kaneko, Hirohiko Hohjoh

MED - United Centers for Advanced Research and Translational Medicine (ART)

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Inflammation is profoundly involved in the development of Alzheimer's disease (AD) and other neurodegenerative diseases. Chemokine, CXC motif, ligand 1 (CXCL1; or GRO1) is an inflammatory cytokine and appears to be implicated in the pathogenesis of AD. It is of interest and importance to see if the CXCL1 gene, mapped on chromosome 4q12-q13, has potential for conferring the predisposition to AD. Here we report on an association study of the CXCL1 gene with sporadic AD patients in a Japanese population; three single nucleotide polymorphisms (SNPs) in the CXCL1 locus were investigated in 103 AD patients and 130 healthy individuals. The results indicate that neither genotype frequencies nor allele frequencies of the examined SNPs attained statistical significance even after being stratified by the presence or absence of the Apolipoprotein E ε4 allele. Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population.

Original language	English
Pages (from-to)	149-151
Number of pages	3
Journal	Neuroscience Letters
Volume	379
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2004.12.056
Publication status	Published - 2005 May 13

Keywords

Alzheimer' disease
Association study
CXC motif, ligand 1 (CXCL1)
Chemokine
Single nucleotide polymorphisms (SNPs)

ASJC Scopus subject areas

Neuroscience(all)

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Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. / Tamura, Yoshiko; Sakasegawa, Yuji; Omi, Kazuya; Kishida, Hitaru; Asada, Takashi; Kimura, Hideo; Tokunaga, Katsushi; Hachiya, Naomi S.; Kaneko, Kiyotoshi; Hohjoh, Hirohiko.

In: Neuroscience Letters, Vol. 379, No. 3, 13.05.2005, p. 149-151.

Research output: Contribution to journal › Article › peer-review

Tamura, Yoshiko ; Sakasegawa, Yuji ; Omi, Kazuya ; Kishida, Hitaru ; Asada, Takashi ; Kimura, Hideo ; Tokunaga, Katsushi ; Hachiya, Naomi S. ; Kaneko, Kiyotoshi ; Hohjoh, Hirohiko. / Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. In: Neuroscience Letters. 2005 ; Vol. 379, No. 3. pp. 149-151.

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title = "Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population",

abstract = "Inflammation is profoundly involved in the development of Alzheimer's disease (AD) and other neurodegenerative diseases. Chemokine, CXC motif, ligand 1 (CXCL1; or GRO1) is an inflammatory cytokine and appears to be implicated in the pathogenesis of AD. It is of interest and importance to see if the CXCL1 gene, mapped on chromosome 4q12-q13, has potential for conferring the predisposition to AD. Here we report on an association study of the CXCL1 gene with sporadic AD patients in a Japanese population; three single nucleotide polymorphisms (SNPs) in the CXCL1 locus were investigated in 103 AD patients and 130 healthy individuals. The results indicate that neither genotype frequencies nor allele frequencies of the examined SNPs attained statistical significance even after being stratified by the presence or absence of the Apolipoprotein E ε4 allele. Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population.",

keywords = "Alzheimer' disease, Association study, CXC motif, ligand 1 (CXCL1), Chemokine, Single nucleotide polymorphisms (SNPs)",

author = "Yoshiko Tamura and Yuji Sakasegawa and Kazuya Omi and Hitaru Kishida and Takashi Asada and Hideo Kimura and Katsushi Tokunaga and Hachiya, {Naomi S.} and Kiyotoshi Kaneko and Hirohiko Hohjoh",

note = "Funding Information: We would like to thank Dr. N. Minami for providing the DNA samples of patients. This work was supported by the Millennium Project of Alzheimer's Disease in Japan.",

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AU - Tamura, Yoshiko

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AU - Omi, Kazuya

AU - Kishida, Hitaru

AU - Asada, Takashi

AU - Kimura, Hideo

AU - Tokunaga, Katsushi

AU - Hachiya, Naomi S.

AU - Kaneko, Kiyotoshi

AU - Hohjoh, Hirohiko

N1 - Funding Information: We would like to thank Dr. N. Minami for providing the DNA samples of patients. This work was supported by the Millennium Project of Alzheimer's Disease in Japan.

PY - 2005/5/13

Y1 - 2005/5/13

N2 - Inflammation is profoundly involved in the development of Alzheimer's disease (AD) and other neurodegenerative diseases. Chemokine, CXC motif, ligand 1 (CXCL1; or GRO1) is an inflammatory cytokine and appears to be implicated in the pathogenesis of AD. It is of interest and importance to see if the CXCL1 gene, mapped on chromosome 4q12-q13, has potential for conferring the predisposition to AD. Here we report on an association study of the CXCL1 gene with sporadic AD patients in a Japanese population; three single nucleotide polymorphisms (SNPs) in the CXCL1 locus were investigated in 103 AD patients and 130 healthy individuals. The results indicate that neither genotype frequencies nor allele frequencies of the examined SNPs attained statistical significance even after being stratified by the presence or absence of the Apolipoprotein E ε4 allele. Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population.

AB - Inflammation is profoundly involved in the development of Alzheimer's disease (AD) and other neurodegenerative diseases. Chemokine, CXC motif, ligand 1 (CXCL1; or GRO1) is an inflammatory cytokine and appears to be implicated in the pathogenesis of AD. It is of interest and importance to see if the CXCL1 gene, mapped on chromosome 4q12-q13, has potential for conferring the predisposition to AD. Here we report on an association study of the CXCL1 gene with sporadic AD patients in a Japanese population; three single nucleotide polymorphisms (SNPs) in the CXCL1 locus were investigated in 103 AD patients and 130 healthy individuals. The results indicate that neither genotype frequencies nor allele frequencies of the examined SNPs attained statistical significance even after being stratified by the presence or absence of the Apolipoprotein E ε4 allele. Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population.

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Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population

Abstract

Keywords

ASJC Scopus subject areas

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