Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population

Yoshiko Tamura, Yuji Sakasegawa, Kazuya Omi, Hitaru Kishida, Takashi Asada, Hideo Kimura, Katsushi Tokunaga, Naomi S. Hachiya, Kiyotoshi Kaneko, Hirohiko Hohjoh

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Inflammation is profoundly involved in the development of Alzheimer's disease (AD) and other neurodegenerative diseases. Chemokine, CXC motif, ligand 1 (CXCL1; or GRO1) is an inflammatory cytokine and appears to be implicated in the pathogenesis of AD. It is of interest and importance to see if the CXCL1 gene, mapped on chromosome 4q12-q13, has potential for conferring the predisposition to AD. Here we report on an association study of the CXCL1 gene with sporadic AD patients in a Japanese population; three single nucleotide polymorphisms (SNPs) in the CXCL1 locus were investigated in 103 AD patients and 130 healthy individuals. The results indicate that neither genotype frequencies nor allele frequencies of the examined SNPs attained statistical significance even after being stratified by the presence or absence of the Apolipoprotein E ε4 allele. Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalNeuroscience Letters
Volume379
Issue number3
DOIs
Publication statusPublished - 2005 May 13

Keywords

  • Alzheimer' disease
  • Association study
  • CXC motif, ligand 1 (CXCL1)
  • Chemokine
  • Single nucleotide polymorphisms (SNPs)

ASJC Scopus subject areas

  • Neuroscience(all)

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