Association of vegetable and fruit intake with gastric cancer risk among Japanese: A pooled analysis of four cohort studies

Taichi Shimazu, K. Wakai, A. Tamakoshi, I. Tsuji, K. Tanaka, K. Matsuo, C. Nagata, T. Mizoue, M. Inoue, S. Tsugane, S. Sasazuki, Shizuka Sasazuki, Shoichiro Tsugane, Manami Inoue, Motoki Iwasaki, Tetsuya Otani, Norie Sawada, Taiki Yamaji, Ichiro Tsuji, Yoshitaka TsubonoYoshikazu Nishino, Keitaro Matsuo, Hidemi Ito, Chisato Nagata, Tetsuya Mizoue, Keitaro Tanaka

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Background: Prospective evidence is inconsistent regarding the association between vegetable/fruit intake and the risk of gastric cancer. Methods: In an analysis of original data from four population-based prospective cohort studies encompassing 191 232 participants, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of gastric cancer incidence according to vegetable and fruit intake and conducted a meta-analysis of HRs derived from each study. Results: During 2 094 428 person-years of follow-up, 2995 gastric cancer cases were identified. After adjustment for potential confounders, we found a marginally significant decrease in gastric cancer risk in relation to total vegetable intake but not total fruit intake: the multivariate-adjusted HR (95% CI; P for trend) for the highest versus the lowest quintile of total vegetable intake was 0.89 (0.77-1.03; P for trend = 0.13) among men and 0.83 (0.67-1.03; P for trend = 0.40) among women. For distal gastric cancer, the multivariate HR for the highest quintile of total vegetable intake was 0.78 (0.63-0.97; P for trend = 0.02) among men. Conclusion(s): This pooled analysis of data from large prospective studies in Japan suggests that vegetable intake reduces gastric cancer risk, especially the risk of distal gastric cancer among men.

Original languageEnglish
Pages (from-to)1228-1233
Number of pages6
JournalAnnals of Oncology
Issue number6
Publication statusPublished - 2014 Jun 1


  • Epidemiology
  • Fruit
  • Pooled analysis
  • Prospective studies
  • Stomach neoplasms
  • Vegetables

ASJC Scopus subject areas

  • Hematology
  • Oncology


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