Association of vegetable and fruit intake with gastric cancer risk among Japanese: A pooled analysis of four cohort studies

Taichi Shimazu; K. Wakai; A. Tamakoshi; I. Tsuji; K. Tanaka; K. Matsuo; C. Nagata; T. Mizoue; M. Inoue; S. Tsugane; S. Sasazuki; Shizuka Sasazuki; Shoichiro Tsugane; Manami Inoue; Motoki Iwasaki; Tetsuya Otani; Norie Sawada; Taiki Yamaji; Ichiro Tsuji; Yoshitaka Tsubono; Yoshikazu Nishino; Keitaro Matsuo; Hidemi Ito; Chisato Nagata; Tetsuya Mizoue; Keitaro Tanaka

doi:10.1093/annonc/mdu115

Association of vegetable and fruit intake with gastric cancer risk among Japanese: A pooled analysis of four cohort studies

Taichi Shimazu, K. Wakai, A. Tamakoshi, I. Tsuji, K. Tanaka, K. Matsuo, C. Nagata, T. Mizoue, M. Inoue, S. Tsugane, S. Sasazuki, Shizuka Sasazuki, Shoichiro Tsugane, Manami Inoue, Motoki Iwasaki, Tetsuya Otani, Norie Sawada, Taiki Yamaji, Ichiro Tsuji, Yoshitaka TsubonoYoshikazu Nishino, Keitaro Matsuo, Hidemi Ito, Chisato Nagata, Tetsuya Mizoue, Keitaro Tanaka

MED - Public Health

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Background: Prospective evidence is inconsistent regarding the association between vegetable/fruit intake and the risk of gastric cancer. Methods: In an analysis of original data from four population-based prospective cohort studies encompassing 191 232 participants, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of gastric cancer incidence according to vegetable and fruit intake and conducted a meta-analysis of HRs derived from each study. Results: During 2 094 428 person-years of follow-up, 2995 gastric cancer cases were identified. After adjustment for potential confounders, we found a marginally significant decrease in gastric cancer risk in relation to total vegetable intake but not total fruit intake: the multivariate-adjusted HR (95% CI; P for trend) for the highest versus the lowest quintile of total vegetable intake was 0.89 (0.77-1.03; P for trend = 0.13) among men and 0.83 (0.67-1.03; P for trend = 0.40) among women. For distal gastric cancer, the multivariate HR for the highest quintile of total vegetable intake was 0.78 (0.63-0.97; P for trend = 0.02) among men. Conclusion(s): This pooled analysis of data from large prospective studies in Japan suggests that vegetable intake reduces gastric cancer risk, especially the risk of distal gastric cancer among men.

Original language	English
Pages (from-to)	1228-1233
Number of pages	6
Journal	Annals of Oncology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1093/annonc/mdu115
Publication status	Published - 2014 Jun 1

Keywords

Epidemiology
Fruit
Pooled analysis
Prospective studies
Stomach neoplasms
Vegetables

ASJC Scopus subject areas

Hematology
Oncology

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Shimazu, T., Wakai, K., Tamakoshi, A., Tsuji, I., Tanaka, K., Matsuo, K., Nagata, C., Mizoue, T., Inoue, M., Tsugane, S., Sasazuki, S., Sasazuki, S., Tsugane, S., Inoue, M., Iwasaki, M., Otani, T., Sawada, N., Yamaji, T., Tsuji, I., ... Tanaka, K. (2014). Association of vegetable and fruit intake with gastric cancer risk among Japanese: A pooled analysis of four cohort studies. Annals of Oncology, 25(6), 1228-1233. https://doi.org/10.1093/annonc/mdu115

Association of vegetable and fruit intake with gastric cancer risk among Japanese : A pooled analysis of four cohort studies. / Shimazu, Taichi; Wakai, K.; Tamakoshi, A.; Tsuji, I.; Tanaka, K.; Matsuo, K.; Nagata, C.; Mizoue, T.; Inoue, M.; Tsugane, S.; Sasazuki, S.; Sasazuki, Shizuka; Tsugane, Shoichiro; Inoue, Manami; Iwasaki, Motoki; Otani, Tetsuya; Sawada, Norie; Yamaji, Taiki; Tsuji, Ichiro; Tsubono, Yoshitaka; Nishino, Yoshikazu; Matsuo, Keitaro; Ito, Hidemi; Nagata, Chisato; Mizoue, Tetsuya; Tanaka, Keitaro.

In: Annals of Oncology, Vol. 25, No. 6, 01.06.2014, p. 1228-1233.

Research output: Contribution to journal › Article › peer-review

Shimazu, T, Wakai, K, Tamakoshi, A, Tsuji, I, Tanaka, K, Matsuo, K, Nagata, C, Mizoue, T, Inoue, M, Tsugane, S, Sasazuki, S, Sasazuki, S, Tsugane, S, Inoue, M, Iwasaki, M, Otani, T, Sawada, N, Yamaji, T, Tsuji, I, Tsubono, Y, Nishino, Y, Matsuo, K, Ito, H, Nagata, C, Mizoue, T & Tanaka, K 2014, 'Association of vegetable and fruit intake with gastric cancer risk among Japanese: A pooled analysis of four cohort studies', Annals of Oncology, vol. 25, no. 6, pp. 1228-1233. https://doi.org/10.1093/annonc/mdu115

Shimazu, Taichi ; Wakai, K. ; Tamakoshi, A. ; Tsuji, I. ; Tanaka, K. ; Matsuo, K. ; Nagata, C. ; Mizoue, T. ; Inoue, M. ; Tsugane, S. ; Sasazuki, S. ; Sasazuki, Shizuka ; Tsugane, Shoichiro ; Inoue, Manami ; Iwasaki, Motoki ; Otani, Tetsuya ; Sawada, Norie ; Yamaji, Taiki ; Tsuji, Ichiro ; Tsubono, Yoshitaka ; Nishino, Yoshikazu ; Matsuo, Keitaro ; Ito, Hidemi ; Nagata, Chisato ; Mizoue, Tetsuya ; Tanaka, Keitaro. / Association of vegetable and fruit intake with gastric cancer risk among Japanese : A pooled analysis of four cohort studies. In: Annals of Oncology. 2014 ; Vol. 25, No. 6. pp. 1228-1233.

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abstract = "Background: Prospective evidence is inconsistent regarding the association between vegetable/fruit intake and the risk of gastric cancer. Methods: In an analysis of original data from four population-based prospective cohort studies encompassing 191 232 participants, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of gastric cancer incidence according to vegetable and fruit intake and conducted a meta-analysis of HRs derived from each study. Results: During 2 094 428 person-years of follow-up, 2995 gastric cancer cases were identified. After adjustment for potential confounders, we found a marginally significant decrease in gastric cancer risk in relation to total vegetable intake but not total fruit intake: the multivariate-adjusted HR (95% CI; P for trend) for the highest versus the lowest quintile of total vegetable intake was 0.89 (0.77-1.03; P for trend = 0.13) among men and 0.83 (0.67-1.03; P for trend = 0.40) among women. For distal gastric cancer, the multivariate HR for the highest quintile of total vegetable intake was 0.78 (0.63-0.97; P for trend = 0.02) among men. Conclusion(s): This pooled analysis of data from large prospective studies in Japan suggests that vegetable intake reduces gastric cancer risk, especially the risk of distal gastric cancer among men.",

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author = "Taichi Shimazu and K. Wakai and A. Tamakoshi and I. Tsuji and K. Tanaka and K. Matsuo and C. Nagata and T. Mizoue and M. Inoue and S. Tsugane and S. Sasazuki and Shizuka Sasazuki and Shoichiro Tsugane and Manami Inoue and Motoki Iwasaki and Tetsuya Otani and Norie Sawada and Taiki Yamaji and Ichiro Tsuji and Yoshitaka Tsubono and Yoshikazu Nishino and Keitaro Matsuo and Hidemi Ito and Chisato Nagata and Tetsuya Mizoue and Keitaro Tanaka",

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T1 - Association of vegetable and fruit intake with gastric cancer risk among Japanese

T2 - A pooled analysis of four cohort studies

AU - Shimazu, Taichi

AU - Wakai, K.

AU - Tamakoshi, A.

AU - Tsuji, I.

AU - Tanaka, K.

AU - Matsuo, K.

AU - Nagata, C.

AU - Mizoue, T.

AU - Inoue, M.

AU - Tsugane, S.

AU - Sasazuki, S.

AU - Sasazuki, Shizuka

AU - Tsugane, Shoichiro

AU - Inoue, Manami

AU - Iwasaki, Motoki

AU - Otani, Tetsuya

AU - Sawada, Norie

AU - Yamaji, Taiki

AU - Tsuji, Ichiro

AU - Tsubono, Yoshitaka

AU - Nishino, Yoshikazu

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Nagata, Chisato

AU - Mizoue, Tetsuya

AU - Tanaka, Keitaro

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Background: Prospective evidence is inconsistent regarding the association between vegetable/fruit intake and the risk of gastric cancer. Methods: In an analysis of original data from four population-based prospective cohort studies encompassing 191 232 participants, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of gastric cancer incidence according to vegetable and fruit intake and conducted a meta-analysis of HRs derived from each study. Results: During 2 094 428 person-years of follow-up, 2995 gastric cancer cases were identified. After adjustment for potential confounders, we found a marginally significant decrease in gastric cancer risk in relation to total vegetable intake but not total fruit intake: the multivariate-adjusted HR (95% CI; P for trend) for the highest versus the lowest quintile of total vegetable intake was 0.89 (0.77-1.03; P for trend = 0.13) among men and 0.83 (0.67-1.03; P for trend = 0.40) among women. For distal gastric cancer, the multivariate HR for the highest quintile of total vegetable intake was 0.78 (0.63-0.97; P for trend = 0.02) among men. Conclusion(s): This pooled analysis of data from large prospective studies in Japan suggests that vegetable intake reduces gastric cancer risk, especially the risk of distal gastric cancer among men.

AB - Background: Prospective evidence is inconsistent regarding the association between vegetable/fruit intake and the risk of gastric cancer. Methods: In an analysis of original data from four population-based prospective cohort studies encompassing 191 232 participants, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of gastric cancer incidence according to vegetable and fruit intake and conducted a meta-analysis of HRs derived from each study. Results: During 2 094 428 person-years of follow-up, 2995 gastric cancer cases were identified. After adjustment for potential confounders, we found a marginally significant decrease in gastric cancer risk in relation to total vegetable intake but not total fruit intake: the multivariate-adjusted HR (95% CI; P for trend) for the highest versus the lowest quintile of total vegetable intake was 0.89 (0.77-1.03; P for trend = 0.13) among men and 0.83 (0.67-1.03; P for trend = 0.40) among women. For distal gastric cancer, the multivariate HR for the highest quintile of total vegetable intake was 0.78 (0.63-0.97; P for trend = 0.02) among men. Conclusion(s): This pooled analysis of data from large prospective studies in Japan suggests that vegetable intake reduces gastric cancer risk, especially the risk of distal gastric cancer among men.

KW - Epidemiology

KW - Fruit

KW - Pooled analysis

KW - Prospective studies

KW - Stomach neoplasms

KW - Vegetables

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