Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphism.

H. Yasuda, S. Okinaga, M. Yamaya, T. Ohrui, M. Higuchi, M. Shinkawa, S. Itabashi, K. Nakayama, M. Asada, A. Kikuchi, S. Shibahara, H. Sasaki

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Abstract

BACKGROUND: Oxidative stresses including cigarette smoking are implicated in the pathogenesis of cerebrovascular diseases, which are associated with pneumonia because of frequent aspiration. Haem oxygenase-1 (HO-1) acts in cytoprotection against oxidants, provides anti-inflammatory effects, and inhibits atherogenesis. A (GT)(n) dinucleotide repeat in the human HO-1 promoter modulates HO-1 gene expression and shows length polymorphism, which is grouped into three classes: class S (<27 repeats), class M (> or = 27, <33 repeats), and class L (> or = 33 repeats) alleles. OBJECTIVE: To investigate the correlation between the HO-1 gene polymorphism and development of pneumonia in elderly Japanese. METHODS: The length of the (GT)n repeats was analysed in 200 elderly patients with pneumonia and 200 control subjects. The association of the HO-1 gene polymorphism with risk of pneumonia was estimated by logistic regression. RESULTS: The proportion of allele frequencies in class L, and the proportion of genotypic frequencies in the L-allele carriers (L/L, L/M, and L/S), was significantly higher in patients with pneumonia than in controls (20% v 10% in class L, and 34% v 18% in L-allele carriers). After adjustment for potentially confounding factors, both cerebrovascular disorders and HO-1 gene L-allele carriers were significant and independent risk factors for pneumonia. The adjusted odds ratio for L-allele carriers v non-L-allele carrier was 2.1 (95% confidence interval, 1.2 to 3.6). CONCLUSIONS: The large size of a (GT)n repeat in the HO-1 gene promoter may be associated with susceptibility to pneumonia in the older Japanese population.

Original languageEnglish
Pages (from-to)e17
JournalJournal of medical genetics
Volume43
Issue number4
DOIs
Publication statusPublished - 2006 Apr

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Yasuda, H., Okinaga, S., Yamaya, M., Ohrui, T., Higuchi, M., Shinkawa, M., Itabashi, S., Nakayama, K., Asada, M., Kikuchi, A., Shibahara, S., & Sasaki, H. (2006). Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphism. Journal of medical genetics, 43(4), e17. https://doi.org/10.1136/jmg.2005.035824