TY - JOUR
T1 - Association of subjective health and abnormal cervical cytology in Japanese pregnant women
T2 - An adjunct study of the Japan Environment and Children's Study
AU - Sasaki, Satomi
AU - Metoki, Hirohito
AU - Satoh, Michihiro
AU - Murakami, Takahisa
AU - Tanoue, Kaou
AU - Tanaka, Kosuke
AU - Iwama, Noriyuki
AU - Watanabe, Zen
AU - Okamoto, Satoshi
AU - Saito, Masatoshi
AU - Sugawara, Junichi
AU - Ito, Kiyoshi
AU - Yaegashi, Nobuo
N1 - Funding Information:
The Japan Environment and Children's Study was funded by the Ministry of the Environment, Government offices of Japan . This adjunct study was supported by JSPS KAKENHI (C) [Grant No 23590771 ], the Kurokawa Cancer Research Foundation, Research Promotion and Practical Use and for Women's Health, AMED. The findings and conclusions of this article are solely the responsibility of the authors and do not represent the official views of the organizations mentioned.
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/12
Y1 - 2021/12
N2 - This study examines the association between abnormal cervical cytology and subjective health in pregnant women, as an adjunct to the Japan Environment and Children's Study, which cross-sectionally analyzed a subset of the prospective cohort. A total of 3024 pregnant women at a childbirth facility whose medical records of cervical cytology in the first trimester of pregnancy were transcribed and who responded to the subjective health questionnaire were included herein. They were classified into excellent, good, fair, and poor groups based on their subjective health. Cervical cytology results obtained from perinatal medical records were classified into normal and abnormal cytology based on the Bethesda classification. Logistic regression analysis adjusted for baseline characteristics, including age, pre-pregnancy body mass index, parity, and other possible confounding factors, was used. Of 3024 pregnant women, 106 (3.5%) had abnormal cytology, with the prevalence being 1.3%, 3.7%, 3.9%, and 4.0%, respectively (p = 0.055) in the poor, fair, good, and excellent groups. The baseline characteristics, namely age, history of gynecological diseases, Kessler 6-item psychological distress scale score, and history of mental illness, were significantly different between groups. Compared to the poor group, the other three groups had a significantly higher abnormal cytology risk after adjusting for confounding factors (Fair: adjusted OR [aOR] = 3.6, 95% CI [1.0–12.1]; Good: aOR = 4.6 [1.3–15.5]; Excellent: aOR = 4.6 [1.2–17.8]). This study encourages young women to undergo cervical cancer screening because they are at risk for cervical cancer even if they think that they are healthy, and preventive activities like regular screening are essential.
AB - This study examines the association between abnormal cervical cytology and subjective health in pregnant women, as an adjunct to the Japan Environment and Children's Study, which cross-sectionally analyzed a subset of the prospective cohort. A total of 3024 pregnant women at a childbirth facility whose medical records of cervical cytology in the first trimester of pregnancy were transcribed and who responded to the subjective health questionnaire were included herein. They were classified into excellent, good, fair, and poor groups based on their subjective health. Cervical cytology results obtained from perinatal medical records were classified into normal and abnormal cytology based on the Bethesda classification. Logistic regression analysis adjusted for baseline characteristics, including age, pre-pregnancy body mass index, parity, and other possible confounding factors, was used. Of 3024 pregnant women, 106 (3.5%) had abnormal cytology, with the prevalence being 1.3%, 3.7%, 3.9%, and 4.0%, respectively (p = 0.055) in the poor, fair, good, and excellent groups. The baseline characteristics, namely age, history of gynecological diseases, Kessler 6-item psychological distress scale score, and history of mental illness, were significantly different between groups. Compared to the poor group, the other three groups had a significantly higher abnormal cytology risk after adjusting for confounding factors (Fair: adjusted OR [aOR] = 3.6, 95% CI [1.0–12.1]; Good: aOR = 4.6 [1.3–15.5]; Excellent: aOR = 4.6 [1.2–17.8]). This study encourages young women to undergo cervical cancer screening because they are at risk for cervical cancer even if they think that they are healthy, and preventive activities like regular screening are essential.
KW - Cervical cancer
KW - HPV
KW - Pregnancy
KW - Screening
KW - Subjective health
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U2 - 10.1016/j.pmedr.2021.101525
DO - 10.1016/j.pmedr.2021.101525
M3 - Article
AN - SCOPUS:85113655522
VL - 24
JO - Preventive Medicine Reports
JF - Preventive Medicine Reports
SN - 2211-3355
M1 - 101525
ER -