Association of rotavirus and human immunodeficiency virus infection in children hospitalized with acute diarrhea, lusaka, zambia

Hitoshi Oshitani, F. C. Kasolo, M. Mpabalwani, N. P. Luo, N. Matsubayasbi, G. H. Bhat, G. H. Bhat, H. Suzuki, Y. Numazaki, A. Zumla, H. L. Du Pont

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

In Lusaka, Zambia, rotavirus (RV) and human immunodeficiency virus (HIV) infection commonly coexist; 132 (25%) of 537 consecutively studied infants <5 years old hospitalized with diarrhea were positive for both viral infections. Infants with RV infection were younger than those who were RV-negative (P>.05), and infants with both viruses more frequently experienced dehydration (P <.05). HIV-infected children more often exhibited respiratory symptoms on admission to the study (P <.0001) and were more frequently underweight (P <.0001) than were HIV-negative children, independent of RV infection. The mortality rate was highest in HIV-positive infants (P <.05), and coinfection with RV did not increase the risk of fatality. This study demonstrates that while RV and HIV infections commonly coexist in one region of Africa, RV infection is no more common nor is the illness more severe in HIV-positive infants.

Original languageEnglish
Pages (from-to)897-900
Number of pages4
JournalJournal of Infectious Diseases
Volume169
Issue number4
DOIs
Publication statusPublished - 1994 Apr 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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