Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease

Toru Baba, Atsushi Takeda, Akio Kikuchi, Yoshiyuki Nishio, Yoshiyuki Hosokai, Kazumi Hirayama, Takafumi Hasegawa, Naoto Sugeno, Kyoko Suzuki, Etsuro Mori, Shoki Takahashi, Hiroshi Fukuda, Yasuto Itoyama

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

Hyposmia is one of the cardinal early symptoms of Parkinson disease (PD). Accumulating clinical and pathological evidence suggests that dysfunction of the olfactory-related cortices may be responsible for the impaired olfactory processing observed in PD; however, there are no clear data showing a direct association between altered brain metabolism and hyposmia in PD. In this study, we evaluated brain glucose metabolism and smell-identification ability in 69 Japanese patients with nondemented PD. Olfactory function was assessed using the Odor Stick Identification Test for Japanese. The regional cerebral metabolic rate of glucose consumption at rest was measured using 18F-fluorodeoxyglucose positron emission tomography and was analyzed using SPM-based group comparisons and the brain-behavior partial least-squares method. We found that olfactory dysfunction was closely related to cognitive dysfunction, including memory impairment. Moreover, brain-behavior partial least-squares analysis revealed that odor-identification performance was closely associated with broad cortical dysfunction, including dysfunction of the piriform cortex and amygdala. Our results suggest that the cognitive deficit in olfactory perception is an important aspect of hyposmia in PD and that this deficit is caused by altered brain metabolism in the amygdala and piriform cortex.

Original languageEnglish
Pages (from-to)621-628
Number of pages8
JournalMovement Disorders
Volume26
Issue number4
DOIs
Publication statusPublished - 2011 Mar

Keywords

  • Cluster analysis
  • Hyposmia
  • PET, amygdala
  • Piriform cortex
  • Spatial covariance analysis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease'. Together they form a unique fingerprint.

Cite this