Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms

Hiroko Sato, Toshihiko Uchida, Kentaro Toyota, Tomohiro Nakamura, Gen Tamiya, Miyako Kanno, Taeko Hashimoto, Masashi Watanabe, Kuraaki Aoki, Kiyoshi Hayasaka

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10 Citations (Scopus)

Abstract

Neonates have physiologically increased bilirubin production and immature bilirubin metabolism, and present hyperbilirubinemia in association with genetic and or epigenetic factors. We previously reported that maximal body weight loss (inadequate feeding) is an independent risk factor for the development of hyperbilirubinemia in breast-fed Japanese neonates, and the UGT1A1 211G>A genotype becomes a risk factor under conditions of inadequate feeding. We extended the study to the association of other genetic factors, the UGT1A1 (TA) 7 and solute-carrier organic anion transporters (SLCOs) polymorphisms with neonatal hyperbilirubinemia. We enrolled 401 full-term Japanese infants who were exclusively breastfeeding and classified them into two groups based on the degree of maximal body weight loss. We analyzed the clinical characteristics and UGT1A1 and SLCOs genotypes. Statistical analysis revealed that maximal body weight loss is the only independent risk factor for the development of neonatal hyperbilirubinemia. UGT1A1, SLCO1B1 and SLCO1B3 polymorphisms become risk factors in neonates showing 10% or greater body weight loss during the neonatal period. Inadequate feeding may increase the bilirubin burden and cause apparent hyperbilirubinemia in neonates, who have a polymorphic change in the genes involved in the transport and/or metabolism of bilirubin.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalJournal of Human Genetics
Volume60
Issue number1
DOIs
Publication statusPublished - 2015 Jan 6

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Sato, H., Uchida, T., Toyota, K., Nakamura, T., Tamiya, G., Kanno, M., Hashimoto, T., Watanabe, M., Aoki, K., & Hayasaka, K. (2015). Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms. Journal of Human Genetics, 60(1), 35-40. https://doi.org/10.1038/jhg.2014.98