Association of glycated albumin with the presence of carotid plaque in patients with type 2 diabetes

Yuki Sato, Mototsugu Nagao, Akira Asai, Yasushi Nakajima, Makiyo Takaya, Naomi Takeichi, Shuji Takemitsu, Mariko Sudo, Toshiko Kano-Wakakuri, Akira Ishizaki, Taro Harada, Kyoko Tanimura-Inagaki, Fumitaka Okajima, Hideki Tamura, Hitoshi Sugihara, Shinichi Oikawa

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)


    Aims/Introduction: Postprandial hyperglycemia is a potent risk factor for cardiovascular disease. Serum glycated albumin (GA) has been reported to reflect postprandial blood glucose fluctuations. In the present study, we assessed the possible correlation of GA with the presence of carotid plaque to evaluate the potential clinical usefulness of GA for predicting atherosclerotic cardiovascular complications in patients with type 2 diabetes. Materials and Methods: Patients with type 2 diabetes (n = 236) admitted to Nippon Medical School Hospital (Tokyo, Japan) for glycemic control (aged 19-86 years, 81 females and 155 males) were examined. Clinical measurements were taken on admission. The presence of carotid plaque was assessed by ultrasonography. Results: In patients with carotid plaque (n = 154), GA (P = 0.023) was higher than those without carotid plaque (n = 82). In contrast, neither fasting plasma glucose (P = 0.48) nor glycated hemoglobin (P = 0.41) was significantly different between the groups. The results of logistic regression analysis showed that GA (age- and sex-adjusted odds ratio [95% confidence interval], 1.05 [1.01-1.09]; P = 0.017) and glycated hemoglobin (1.17 [1.01-1.37]; P = 0.036) were significantly associated with the presence of carotid plaque. Conclusions: The positive correlation of serum GA with the presence of carotid plaque in type 2 diabetes suggests that GA will serve as a useful clinical marker for predicting diabetic cardiovascular complications.

    Original languageEnglish
    Pages (from-to)634-639
    Number of pages6
    JournalJournal of Diabetes Investigation
    Issue number6
    Publication statusPublished - 2013 Nov


    • Carotid plaque
    • Glycated albumin
    • Type 2 diabetes mellitus

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism


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