Association of BMI with the β3-Adrenergic receptor gene polymorphism in Japanese: Meta-analysis

Naoyuki Kurokawa, Kunihiko Nakai, Satomi Kameo, Zhong Min Liu, Hiroshi Satoh

Research output: Contribution to journalArticlepeer-review

89 Citations (Scopus)


Objective: To assess the effect of the Trp64Arg polymorphism in the β3-adrenergic receptor gene (ADRB3) on body mass index (BMI) in the Japanese population. Research Methods and Procedures: We selected studies that evaluated the association between BMI and ADRB3 polymorphism among Japanese, using MEDLINE and PubMed. After data collection, an extension of ANOVA was performed to assess the differences according to the genotype. Results: In a total of 35 subgroups including 2316 subjects with the Trp64Arg variant and 4266 subjects without this variant, the weighted mean difference in BMI was 0.26 kg/m2 (95% confidence interval: 0.18 to 0.42; p < 0.01), indicating that variant carriers exhibited higher BMI than did normal homozygous subjects. Discussion: Although it is known that the allele frequency of the ADRB3 polymorphism differs among races, this study focuses on the Japanese population, which has a high allele frequency of ADRB3 polymorphism. We assumed that statistical errors would be prevented due to the sufficient number of subjects. In conclusion, the results support the hypothesis that ADRB3 gene polymorphism is associated with BMI.

Original languageEnglish
Pages (from-to)741-745
Number of pages5
JournalObesity Research
Issue number12
Publication statusPublished - 2001 Dec


  • Allele frequency
  • Extension of ANOVA
  • Population size

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Public Health, Environmental and Occupational Health


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