Association of alcohol consumption with fat deposition in a community-based sample of Japanese men: The Shiga epidemiological study of subclinical atherosclerosis (SESSA)

Masaki Sumi, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Keiko Kondo, Sayaka Kadowaki, Sentaro Suzuki, Sayuki Torii, Maryam Zaid, Atsushi Sato, Hisatomi Arima, Tomohiro Terada, Katsuyuki Miura, Hirotsugu Ueshima, Minoru Horie, Yasutaka Nakano, Takashi Yamamoto, Hideki Hayashi, Emiko OgawaHiroshi Maegawa, Itsuko Miyazawa, Kiyoshi Murata, Kenichi Mitsunami, Kazuhiko Nozaki, Ikuo Tooyama, Akihiko Shiino, Teruhiko Tsuru, Hisakazu Ogita, Akio Shimizu, Naomi Miyamatsu, Toru Kita, Takeshi Kimura, Yoshihiko Nishio, Yasuyuki Nakamura, Tomonori Okamura, Akira Sekikawa, Emma Jm Barinas-Mitchell, Daniel Edmundowicz, Takayoshi Ohkubo, Atsushi Hozawa, Sendai Miyagi, Yoshitaka Murakami, Nagako Okuda, Yoshikuni Kita, Aya Higashiyama, Shinya Nagasawa, Koichiro Azuma, Masahiko Yanagita, Robert D. Abbott, Seiko Ohno, Naoyuki Takashima, Takashi Kadowaki, Yoshino Saito, Takahiro Ito, Atsushi Satoh, Masahiro Yamazoe

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: Non-drinkers (0 g=week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g=week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg=m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VATto- SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. Conclusions: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
Journaljournal of epidemiology
Volume29
Issue number6
DOIs
Publication statusPublished - 2019 Jun

Keywords

  • Alcohol consumption
  • Anthropometric obesity indice
  • Fat deposition
  • Visceral adipose tissue

ASJC Scopus subject areas

  • Epidemiology

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