TY - JOUR
T1 - Association of a mast cell chymase gene variant with HDL cholesterol, but not with blood pressure in the Ohasama study
AU - Fukuda, Masayuki
AU - Ohkubo, Takayoshi
AU - Katsuya, Tomohiro
AU - Hozawa, Atsushi
AU - Asai, Takashi
AU - Matsubara, Mitsunobu
AU - Kitaoka, Hirofumi
AU - Tsuji, Ichiro
AU - Araki, Tsutomu
AU - Satoh, Hiroshi
AU - Higaki, Jitsuo
AU - Hisamichi, Shigeru
AU - Imai, Yutaka
AU - Ogihara, Toshio
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - Two enzymes, chymase and angiotensin converting enzyme (ACE), are involved in the production of angiotensin II. Our previous study revealed the male-specific effect of the ACE DD genotype on the risk for hypertension, but the genetic role of chymase remains unclear. In the present study, we report the results of an association study involving 1,046 subjects recruited from a general population in Ohasama, a rural community in the northern part of Japan. In addition to casual blood pressure (casual BP) measurement, home BP measurements were obtained from all participants. There were no differences in either home or casual BP values according to G3255A polymorphism of the mast cell chymase gene (MCC). HDL cholesterol level was significantly higher among carriers of the A3255 allele (p<0.04). After adjustment for confounding factors, the A3255 allele was still shown to have an effect on HDL cholesterol metabolism (p<0.03). Multiple regression analysis showed that MCC polymorphism was significantly and independently related to serum HDL cholesterol level. In conclusion, G3255A polymorphism of MCC is not directly associated with blood pressure but may modulate the prevalence of hypertensive complications via alteration of lipid metabolism.
AB - Two enzymes, chymase and angiotensin converting enzyme (ACE), are involved in the production of angiotensin II. Our previous study revealed the male-specific effect of the ACE DD genotype on the risk for hypertension, but the genetic role of chymase remains unclear. In the present study, we report the results of an association study involving 1,046 subjects recruited from a general population in Ohasama, a rural community in the northern part of Japan. In addition to casual blood pressure (casual BP) measurement, home BP measurements were obtained from all participants. There were no differences in either home or casual BP values according to G3255A polymorphism of the mast cell chymase gene (MCC). HDL cholesterol level was significantly higher among carriers of the A3255 allele (p<0.04). After adjustment for confounding factors, the A3255 allele was still shown to have an effect on HDL cholesterol metabolism (p<0.03). Multiple regression analysis showed that MCC polymorphism was significantly and independently related to serum HDL cholesterol level. In conclusion, G3255A polymorphism of MCC is not directly associated with blood pressure but may modulate the prevalence of hypertensive complications via alteration of lipid metabolism.
KW - Chymase
KW - Genetics
KW - HDL cholesterol
KW - Hypertension
KW - Polymorphism
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U2 - 10.1291/hypres.25.179
DO - 10.1291/hypres.25.179
M3 - Article
C2 - 12047032
AN - SCOPUS:0036239990
VL - 25
SP - 179
EP - 184
JO - Hypertension Research
JF - Hypertension Research
SN - 0916-9636
IS - 2
ER -