Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria

Eiji Nagayasu, Koichi Nagakura, Mayumi Akaki, Gen Tamiya, Satoshi Makino, Yamaji Nakano, Minoru Kimura, Masamichi Aikawa

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Experimental severe malaria (ESM; also known as experimental cerebral malaria) is an acute lethal syndrome caused by infection with Plasmodium berghei ANKA and associated with coma and other neurological manifestations in mice. Various inbred strains of mice exhibit differences in susceptibility to the development of ESM. For example, C57BL/6 mice are highly susceptible and DBA/2 mice are relatively resistant. We report here the results of a genomewide scan for host genomic regions that control resistance to ESM in DBA/2 mice using an F2 intercross population of susceptible and resistant strains. A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM.

Original languageEnglish
Pages (from-to)512-516
Number of pages5
JournalInfection and immunity
Volume70
Issue number2
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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