Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria

Eiji Nagayasu; Koichi Nagakura; Mayumi Akaki; Gen Tamiya; Satoshi Makino; Yamaji Nakano; Minoru Kimura; Masamichi Aikawa

doi:10.1128/IAI.70.2.512-516.2002

Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria

Eiji Nagayasu, Koichi Nagakura, Mayumi Akaki, Gen Tamiya, Satoshi Makino, Yamaji Nakano, Minoru Kimura, Masamichi Aikawa

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Experimental severe malaria (ESM; also known as experimental cerebral malaria) is an acute lethal syndrome caused by infection with Plasmodium berghei ANKA and associated with coma and other neurological manifestations in mice. Various inbred strains of mice exhibit differences in susceptibility to the development of ESM. For example, C57BL/6 mice are highly susceptible and DBA/2 mice are relatively resistant. We report here the results of a genomewide scan for host genomic regions that control resistance to ESM in DBA/2 mice using an F₂ intercross population of susceptible and resistant strains. A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM.

Original language	English
Pages (from-to)	512-516
Number of pages	5
Journal	Infection and immunity
Volume	70
Issue number	2
DOIs	https://doi.org/10.1128/IAI.70.2.512-516.2002
Publication status	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/IAI.70.2.512-516.2002

Cite this

@article{6807f53c268b40cd95a4d962123fe153,

title = "Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria",

abstract = "Experimental severe malaria (ESM; also known as experimental cerebral malaria) is an acute lethal syndrome caused by infection with Plasmodium berghei ANKA and associated with coma and other neurological manifestations in mice. Various inbred strains of mice exhibit differences in susceptibility to the development of ESM. For example, C57BL/6 mice are highly susceptible and DBA/2 mice are relatively resistant. We report here the results of a genomewide scan for host genomic regions that control resistance to ESM in DBA/2 mice using an F2 intercross population of susceptible and resistant strains. A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM.",

author = "Eiji Nagayasu and Koichi Nagakura and Mayumi Akaki and Gen Tamiya and Satoshi Makino and Yamaji Nakano and Minoru Kimura and Masamichi Aikawa",

year = "2002",

doi = "10.1128/IAI.70.2.512-516.2002",

language = "English",

volume = "70",

pages = "512--516",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "2",

}

TY - JOUR

T1 - Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria

AU - Nagayasu, Eiji

AU - Nagakura, Koichi

AU - Akaki, Mayumi

AU - Tamiya, Gen

AU - Makino, Satoshi

AU - Nakano, Yamaji

AU - Kimura, Minoru

AU - Aikawa, Masamichi

PY - 2002

Y1 - 2002

N2 - Experimental severe malaria (ESM; also known as experimental cerebral malaria) is an acute lethal syndrome caused by infection with Plasmodium berghei ANKA and associated with coma and other neurological manifestations in mice. Various inbred strains of mice exhibit differences in susceptibility to the development of ESM. For example, C57BL/6 mice are highly susceptible and DBA/2 mice are relatively resistant. We report here the results of a genomewide scan for host genomic regions that control resistance to ESM in DBA/2 mice using an F2 intercross population of susceptible and resistant strains. A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM.

AB - Experimental severe malaria (ESM; also known as experimental cerebral malaria) is an acute lethal syndrome caused by infection with Plasmodium berghei ANKA and associated with coma and other neurological manifestations in mice. Various inbred strains of mice exhibit differences in susceptibility to the development of ESM. For example, C57BL/6 mice are highly susceptible and DBA/2 mice are relatively resistant. We report here the results of a genomewide scan for host genomic regions that control resistance to ESM in DBA/2 mice using an F2 intercross population of susceptible and resistant strains. A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM.

UR - http://www.scopus.com/inward/record.url?scp=0036153576&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036153576&partnerID=8YFLogxK

U2 - 10.1128/IAI.70.2.512-516.2002

DO - 10.1128/IAI.70.2.512-516.2002

M3 - Article

C2 - 11796577

AN - SCOPUS:0036153576

VL - 70

SP - 512

EP - 516

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 2

ER -

Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this