Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability

Melissa Garcia, Chan Choi, Hyeong Rok Kim, Yahya Daoud, Yuji Toiyama, Masanobu Takahashi, Ajay Goel, C. Richard Boland, Minoru Koi

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Colorectal cancer cells frequently have low levels of microsatellite instability (MSI-L) and elevated microsatellite alterations at selected tetranucleotide repeats (EMAST), but little is known about the clinicopathologic significance of these features. We observed that patients with stage II or III colorectal cancer with MSI-L and/or EMAST had shorter times of recurrence-free survival than patients with high levels of MSI (P =.0084) or with highly stable microsatellites P =.0415), based on Kaplan-Meier analysis. MSI-L and/or EMAST were independent predictors of recurrent distant metastasis from primary stage II or III colorectal tumors (Cox proportional hazard analysis: hazard ratio, 1.83; 95% confidence interval, 1.06-3.15; P =.0301).

Original languageEnglish
Pages (from-to)48-50.e1
JournalGastroenterology
Volume143
Issue number1
DOIs
Publication statusPublished - 2012 Jul
Externally publishedYes

Keywords

  • Colorectal Cancer
  • Distant Metastasis
  • Genetic Instability
  • Predictive Factor

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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