Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability

Melissa Garcia; Chan Choi; Hyeong Rok Kim; Yahya Daoud; Yuji Toiyama; Masanobu Takahashi; Ajay Goel; C. Richard Boland; Minoru Koi

doi:10.1053/j.gastro.2012.03.034

Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability

Melissa Garcia, Chan Choi, Hyeong Rok Kim, Yahya Daoud, Yuji Toiyama, Masanobu Takahashi, Ajay Goel, C. Richard Boland, Minoru Koi

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Colorectal cancer cells frequently have low levels of microsatellite instability (MSI-L) and elevated microsatellite alterations at selected tetranucleotide repeats (EMAST), but little is known about the clinicopathologic significance of these features. We observed that patients with stage II or III colorectal cancer with MSI-L and/or EMAST had shorter times of recurrence-free survival than patients with high levels of MSI (P =.0084) or with highly stable microsatellites P =.0415), based on Kaplan-Meier analysis. MSI-L and/or EMAST were independent predictors of recurrent distant metastasis from primary stage II or III colorectal tumors (Cox proportional hazard analysis: hazard ratio, 1.83; 95% confidence interval, 1.06-3.15; P =.0301).

Original language	English
Pages (from-to)	48-50.e1
Journal	Gastroenterology
Volume	143
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2012.03.034
Publication status	Published - 2012 Jul
Externally published	Yes

Keywords

Colorectal Cancer
Distant Metastasis
Genetic Instability
Predictive Factor

ASJC Scopus subject areas

Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1053/j.gastro.2012.03.034

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title = "Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability",

abstract = "Colorectal cancer cells frequently have low levels of microsatellite instability (MSI-L) and elevated microsatellite alterations at selected tetranucleotide repeats (EMAST), but little is known about the clinicopathologic significance of these features. We observed that patients with stage II or III colorectal cancer with MSI-L and/or EMAST had shorter times of recurrence-free survival than patients with high levels of MSI (P =.0084) or with highly stable microsatellites P =.0415), based on Kaplan-Meier analysis. MSI-L and/or EMAST were independent predictors of recurrent distant metastasis from primary stage II or III colorectal tumors (Cox proportional hazard analysis: hazard ratio, 1.83; 95% confidence interval, 1.06-3.15; P =.0301).",

keywords = "Colorectal Cancer, Distant Metastasis, Genetic Instability, Predictive Factor",

author = "Melissa Garcia and Chan Choi and Kim, {Hyeong Rok} and Yahya Daoud and Yuji Toiyama and Masanobu Takahashi and Ajay Goel and Boland, {C. Richard} and Minoru Koi",

note = "Funding Information: Funding Supported by National Institutes of Health grant R01 CA72851 (C.R.B.) and a pilot grant from the Sammons Cancer Center at Baylor University Medical Center (M.K.). ",

year = "2012",

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doi = "10.1053/j.gastro.2012.03.034",

language = "English",

volume = "143",

pages = "48--50.e1",

journal = "Gastroenterology",

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T1 - Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability

AU - Garcia, Melissa

AU - Choi, Chan

AU - Kim, Hyeong Rok

AU - Daoud, Yahya

AU - Toiyama, Yuji

AU - Takahashi, Masanobu

AU - Goel, Ajay

AU - Boland, C. Richard

AU - Koi, Minoru

N1 - Funding Information: Funding Supported by National Institutes of Health grant R01 CA72851 (C.R.B.) and a pilot grant from the Sammons Cancer Center at Baylor University Medical Center (M.K.).

PY - 2012/7

Y1 - 2012/7

N2 - Colorectal cancer cells frequently have low levels of microsatellite instability (MSI-L) and elevated microsatellite alterations at selected tetranucleotide repeats (EMAST), but little is known about the clinicopathologic significance of these features. We observed that patients with stage II or III colorectal cancer with MSI-L and/or EMAST had shorter times of recurrence-free survival than patients with high levels of MSI (P =.0084) or with highly stable microsatellites P =.0415), based on Kaplan-Meier analysis. MSI-L and/or EMAST were independent predictors of recurrent distant metastasis from primary stage II or III colorectal tumors (Cox proportional hazard analysis: hazard ratio, 1.83; 95% confidence interval, 1.06-3.15; P =.0301).

AB - Colorectal cancer cells frequently have low levels of microsatellite instability (MSI-L) and elevated microsatellite alterations at selected tetranucleotide repeats (EMAST), but little is known about the clinicopathologic significance of these features. We observed that patients with stage II or III colorectal cancer with MSI-L and/or EMAST had shorter times of recurrence-free survival than patients with high levels of MSI (P =.0084) or with highly stable microsatellites P =.0415), based on Kaplan-Meier analysis. MSI-L and/or EMAST were independent predictors of recurrent distant metastasis from primary stage II or III colorectal tumors (Cox proportional hazard analysis: hazard ratio, 1.83; 95% confidence interval, 1.06-3.15; P =.0301).

KW - Colorectal Cancer

KW - Distant Metastasis

KW - Genetic Instability

KW - Predictive Factor

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SN - 0016-5085

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JO - Gastroenterology

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Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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