TY - JOUR
T1 - Association between pesticide usage during pregnancy and neonatal hyperbilirubinemia requiring treatment
T2 - the Japan Environment and Children’s Study
AU - The Japan Environment & Children’s Study (JECS) Group
AU - Shibazaki, Takumi
AU - Motoki, Noriko
AU - Misawa, Yuka
AU - Ohira, Satoshi
AU - Inaba, Yuji
AU - Kanai, Makoto
AU - Kurita, Hiroshi
AU - Nakazawa, Yozo
AU - Tsukahara, Teruomi
AU - Nomiyama, Tetsuo
AU - Kawamoto, Toshihiro
AU - Saito, Hirohisa
AU - Kishi, Reiko
AU - Yaegashi, Nobuo
AU - Hashimoto, Koichi
AU - Mori, Chisato
AU - Ito, Shuichi
AU - Yamagata, Zentaro
AU - Inadera, Hidekuni
AU - Kamijima, Michihiro
AU - Nakayama, Takeo
AU - Iso, Hiroyasu
AU - Shima, Masayuki
AU - Hirooka, Yasuaki
AU - Suganuma, Narufumi
AU - Kusuhara, Koichi
AU - Katoh, Takahiko
N1 - Funding Information:
This research was supported by The Japan Environment and Children’s Study (JECS) Group. We sincerely thank all the participants in this study and all individuals involved in data collection. The Japan Environment and Children’s Study was funded by the Ministry of the Environment of the Government of Japan. The finding and conclusions of this study are solely the response of the authors and do not represent the official views of the above government.
Publisher Copyright:
© 2020, International Pediatric Research Foundation, Inc.
PY - 2021/5
Y1 - 2021/5
N2 - Background: Maternal exposure to pesticides during pregnancy may cause oxidative hemolysis leading to neonatal hyperbilirubinemia. This investigation examined for associations between maternal use of pesticides or repellents during pregnancy and neonatal hyperbilirubinemia requiring phototherapy. Methods: We used the dataset from the Japan Environment and Children’s Study, a large national birth cohort study registered from January 31, 2011 to March 31, 2014. The fixed data of 61,751 live births were used to evaluate the presence of neonatal hyperbilirubinemia and potential confounding factors. We employed multiple logistic regression analysis to identify correlations between the frequency of maternal pesticide or repellent use during pregnancy and clinically relevant neonatal hyperbilirubinemia. Results: After controlling for confounding factors, there were significant associations between neonatal hyperbilirubinemia necessitating phototherapy and the frequent use of indoor insecticide spray (OR 1.21, 95% CI 1.05–1.38). For spray- or lotion-type insect repellents, an opposite relationship was observed (more than a few times a week: OR 0.70, 95% CI 0.61–0.81, up to a few times a month: OR 0.84, 95% CI 0.78–0.91). Conclusion: The frequent use of indoor insecticide spray during pregnancy showed an increased risk of neonatal hyperbilirubinemia requiring phototherapy, which was absent for spray- or lotion-type insect repellents. Impact: The frequent use of indoor insecticide spray during pregnancy showed an increased risk of neonatal hyperbilirubinemia requiring phototherapy, which was absent for spray- or lotion-type insect repellents.This is the first study examining the effects of maternal exposure to pesticides or repellents on clinically relevant neonatal hyperbilirubinemia using a dataset from a nationwide birth cohort study.This large-scale Japanese cohort study revealed that the frequent use of indoor insecticide spray during pregnancy may increase the risk of neonatal hyperbilirubinemia requiring treatment.
AB - Background: Maternal exposure to pesticides during pregnancy may cause oxidative hemolysis leading to neonatal hyperbilirubinemia. This investigation examined for associations between maternal use of pesticides or repellents during pregnancy and neonatal hyperbilirubinemia requiring phototherapy. Methods: We used the dataset from the Japan Environment and Children’s Study, a large national birth cohort study registered from January 31, 2011 to March 31, 2014. The fixed data of 61,751 live births were used to evaluate the presence of neonatal hyperbilirubinemia and potential confounding factors. We employed multiple logistic regression analysis to identify correlations between the frequency of maternal pesticide or repellent use during pregnancy and clinically relevant neonatal hyperbilirubinemia. Results: After controlling for confounding factors, there were significant associations between neonatal hyperbilirubinemia necessitating phototherapy and the frequent use of indoor insecticide spray (OR 1.21, 95% CI 1.05–1.38). For spray- or lotion-type insect repellents, an opposite relationship was observed (more than a few times a week: OR 0.70, 95% CI 0.61–0.81, up to a few times a month: OR 0.84, 95% CI 0.78–0.91). Conclusion: The frequent use of indoor insecticide spray during pregnancy showed an increased risk of neonatal hyperbilirubinemia requiring phototherapy, which was absent for spray- or lotion-type insect repellents. Impact: The frequent use of indoor insecticide spray during pregnancy showed an increased risk of neonatal hyperbilirubinemia requiring phototherapy, which was absent for spray- or lotion-type insect repellents.This is the first study examining the effects of maternal exposure to pesticides or repellents on clinically relevant neonatal hyperbilirubinemia using a dataset from a nationwide birth cohort study.This large-scale Japanese cohort study revealed that the frequent use of indoor insecticide spray during pregnancy may increase the risk of neonatal hyperbilirubinemia requiring treatment.
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U2 - 10.1038/s41390-020-1100-6
DO - 10.1038/s41390-020-1100-6
M3 - Article
C2 - 32756550
AN - SCOPUS:85089138968
VL - 89
SP - 1565
EP - 1570
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 6
ER -