Association between maternal smoking during pregnancy and birth weight: An appropriately adjusted model from the Japan environment and children's study

Japan Environment and Children's Study (JECS) Group

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: There has been no large nationwide population-based study to examine the effects of maternal smoking status during pregnancy on birth weight that simultaneously controlled for clinical information, socioeconomic status, and maternal weight. Thus, this study aimed to determine the association between maternal smoking status during pregnancy and birth weight, while taking these confounding factors into consideration. Methods: This study examined the first-year fixed dataset from a large nationwide birth cohort study that commenced in 2011. The dataset consisted of information on 9369 singleton infants born before December 31, 2011. Children were divided into 4 groups for statistical analysis: those born to mothers who did not smoke (NS), who quit smoking before pregnancy, who quit smoking during early pregnancy, and who smoked (SM). Multiple linear regression models were conducted for each sex to examine the association between maternal smoking status during early pregnancy and fetal growth. Birth weight was estimated using the least-squares method after controlling for covariates. Results: After controlling for potential confounding factors, maternal smoking status during pregnancy was significantly associated with birth weight. There was a significant difference in birth weight between NS and SM for both male and female infants (male infants, 3096.2 g [NS] vs 2959.8 g [SM], P < 0.001; female infants, 3018.2 g [NS] vs 2893.7 g [SM], P < 0.001). Conclusions: Using data from a large nationwide birth cohort study in Japan, we have shown that maternal smoking during pregnancy may reduce birth weight by 125-136 g.

Original languageEnglish
Pages (from-to)371-377
Number of pages7
Journaljournal of epidemiology
Volume26
Issue number7
DOIs
Publication statusPublished - 2016

Keywords

  • Birth weight
  • Pregnancy
  • Smoking

ASJC Scopus subject areas

  • Epidemiology

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