TY - JOUR
T1 - Association between maternal alcohol consumption during pregnancy and risk of preterm delivery
T2 - the Japan Environment and Children's Study
AU - the Japan Environment Children's Study Group
AU - Ikehara, S.
AU - Kimura, T.
AU - Kakigano, A.
AU - Sato, T.
AU - Iso, H.
AU - Saito, Hirohisa
AU - Kishi, Reiko
AU - Yaegashi, Nobuo
AU - Hashimoto, Koichi
AU - Mori, Chisato
AU - Ito, Shuichi
AU - Yamagata, Zentaro
AU - Inadera, Hidekuni
AU - Kamijima, Michihiro
AU - Nakayama, Takeo
AU - Shima, Masayuki
AU - Hirooka, Yasuaki
AU - Suganuma, Narufumi
AU - Kusuhara, Koichi
AU - Katoh, Takahiko
N1 - Funding Information:
The JECS was funded by the Ministry of the Environment, Japan (direct funding, no funding IDs available).
Funding Information:
The JECS was funded by the Ministry of the Environment, Japan (direct funding, no funding IDs available). We are grateful to all JECS participants and all individuals involved in data collection. JECS was funded by the Japanese Ministry of the Environment. The findings and conclusions of this paper are solely the responsibility of the authors and do not represent official views of the above government agency.
Funding Information:
We are grateful to all JECS participants and all individuals involved in data collection. JECS was funded by the Japanese Ministry of the Environment. The findings and conclusions of this paper are solely the responsibility of the authors and do not represent official views of the above government agency.
Publisher Copyright:
© 2019 Royal College of Obstetricians and Gynaecologists
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Objective: To examine the association between maternal alcohol consumption during pregnancy and the risk of preterm delivery. Design: Prospective cohort study. Setting: The Japan Environment and Children's Study (JECS). Population: A total of 94 349 singleton pregnancies. Methods: Participants completed questionnaires detailing alcohol consumption during the first trimester and during the second and third trimesters. Participants were divided into four categories according to alcohol consumption (non-drinkers, consumers of 1–149 g, 150–299 g and ≥300 g ethanol/week). We examined the effect of alcohol consumption during different stages of pregnancy on the risk of preterm delivery. Odds ratios (OR) and 95% CI were calculated relative to non-drinkers using logistic regression. Main outcome measures: Medical record-based preterm delivery. Results: Alcohol consumption during the second and third trimesters, but not during the first trimester, was associated with increased risk of preterm delivery. Heavy alcohol consumption (≥300 g ethanol/week) during the second and third trimesters was associated with a four-fold higher risk compared with non-drinkers (multivariable OR 4.52; 95% CI 1.68–12.2). Light alcohol consumption (1–149 g ethanol/week) tended to be associated with lower risk of preterm delivery (multivariable OR 0.78; 95% CI 0.60–1.00). Conclusions: Heavy alcohol consumption during the second and third trimesters was associated with increased risk of preterm delivery among pregnant women. Tweetable abstract: Heavy drinking during pregnancy may increase the risk of preterm delivery.
AB - Objective: To examine the association between maternal alcohol consumption during pregnancy and the risk of preterm delivery. Design: Prospective cohort study. Setting: The Japan Environment and Children's Study (JECS). Population: A total of 94 349 singleton pregnancies. Methods: Participants completed questionnaires detailing alcohol consumption during the first trimester and during the second and third trimesters. Participants were divided into four categories according to alcohol consumption (non-drinkers, consumers of 1–149 g, 150–299 g and ≥300 g ethanol/week). We examined the effect of alcohol consumption during different stages of pregnancy on the risk of preterm delivery. Odds ratios (OR) and 95% CI were calculated relative to non-drinkers using logistic regression. Main outcome measures: Medical record-based preterm delivery. Results: Alcohol consumption during the second and third trimesters, but not during the first trimester, was associated with increased risk of preterm delivery. Heavy alcohol consumption (≥300 g ethanol/week) during the second and third trimesters was associated with a four-fold higher risk compared with non-drinkers (multivariable OR 4.52; 95% CI 1.68–12.2). Light alcohol consumption (1–149 g ethanol/week) tended to be associated with lower risk of preterm delivery (multivariable OR 0.78; 95% CI 0.60–1.00). Conclusions: Heavy alcohol consumption during the second and third trimesters was associated with increased risk of preterm delivery among pregnant women. Tweetable abstract: Heavy drinking during pregnancy may increase the risk of preterm delivery.
KW - Alcohol consumption
KW - pregnant women
KW - preterm delivery
KW - prospective study
KW - the Japan Environment and Children's Study (JECS)
UR - http://www.scopus.com/inward/record.url?scp=85071108562&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071108562&partnerID=8YFLogxK
U2 - 10.1111/1471-0528.15899
DO - 10.1111/1471-0528.15899
M3 - Article
C2 - 31386246
AN - SCOPUS:85071108562
VL - 126
SP - 1448
EP - 1454
JO - The Journal of obstetrics and gynaecology of the British Empire
JF - The Journal of obstetrics and gynaecology of the British Empire
SN - 1470-0328
IS - 12
ER -