Association between body mass index and the colorectal cancer risk in Japan: Pooled analysis of population-based cohort studies in Japan

K. Matsuo, T. Mizoue, K. Tanaka, I. Tsuji, Y. Sugawara, S. Sasazuki, C. Nagata, A. Tamakoshi, K. Wakai, M. Inoue, S. Tsugane

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Background: Obesity has been recognized as important risk factors for colorectal cancer. However, limited evidence is available on colorectal cancer and body mass index (BMI) in Asian population. Methods: We conducted a pooled analysis of eight population-based prospective cohorts studies in Japan with more than 300 000 subjects to evaluate an impact of obesity in terms of BMI on colorectal cancer risk with unified categories. We estimated summary hazard ratio (HR) by pooling of study-specific HR for BMI categories with random effect model. Results: We found a significant positive association between BMI and colorectal cancer risk in male and female. Adjusted HRs for 1 kg/m 2 increase were 1.03 [95% confidence interval (CI) 1.02-1.04] for males and 1.02 (95% CI 1.00-1.03) for females. The association was stronger in colon, especially in proximal colon, relative to rectum. Males showed a stronger association than females. Population attributable fraction for colorectal cancer by BMI ≥25 kg/m 2 was 3.62% (95% CI 1.91-5.30) for males and 2.62% (95% CI 0.74-4.47) for females. Conclusions: We found significant association between BMI and colorectal cancer risk by pooling of data from cohort studies with considerable number of subjects among Japanese population. This information is important in cancer control planning, especially in Asian population.

Original languageEnglish
Pages (from-to)479-490
Number of pages12
JournalAnnals of Oncology
Volume23
Issue number2
DOIs
Publication statusPublished - 2012 Feb

Keywords

  • Body mass index
  • Cohort study
  • Colorectal cancer
  • Japanese
  • Obesity
  • Pooled analysis

ASJC Scopus subject areas

  • Hematology
  • Oncology

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