Association between beta3-adrenergic receptor Trp64Arg polymorphism and fat preference in healthy young japanese women

Kei Watanabe, Guang Hong, Kanako Tominami, Satoshi Izumi, Yohei Hayashi, Tada Aki Kudo

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Beta3-adrenergic receptor (ADRB3) is a mediator of catecholamine-stimulated lipolysis in humans. The Trp64Arg polymorphism with T/C transition in the ADRB3 gene has been considered to reduce lipolysis and metabolic expenditure. Here, we investigated the hitherto unknown role of the Trp64Arg substitution on food preference among healthy young adults (mean age, 24.3; n = 53, including 25 men). Preference toward four food types (bitter, sour, salty, or sweet) and greasy (high-fat) foods was examined using a self-reported questionnaire. There was no noticeable sex-difference in food preference. Incidentally, only among female subjects, the genotype frequencies of the Trp64Arg polymorphism were in accordance with the Hardy-Weinberg equilibrium. Consequently, female subjects were divided into two groups for further analyses: 18 subjects with TT genotype (Trp64Trp) (wild-type group) and 10 subjects with TC genotype (Trp64Arg) (heterozygous group). No significant difference was observed in preference for four food types between the groups. However, when sweet foods were divided into high-fat and low-fat subgroups, food preference for high-fat sweet foods in heterozygous group was significantly higher than that in wild-type group. Moreover, when subjects were divided into two classes based on preference for greasy foods (like, n = 16 or dislike, n = 12), the preference degree in heterozygous group who liked high-fat foods (n = 5) was significantly higher than that in wild-type group (n = 11), suggesting that the Trp64Arg substitution might genetically enhance high-fat food preference. Thus, understanding the relationship between ADRB3 Trp64Arg substitution and fat preference will be valuable for obesity prevention.

Original languageEnglish
Pages (from-to)181-192
Number of pages12
JournalTohoku Journal of Experimental Medicine
Issue number3
Publication statusPublished - 2019


  • Beta3-adrenergic receptor
  • Fat metabolism
  • Food preference
  • High-fat foods
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Association between beta3-adrenergic receptor Trp64Arg polymorphism and fat preference in healthy young japanese women'. Together they form a unique fingerprint.

Cite this