Objective. The purpose of this study was to determine whether there is a relationship between synovial fluid levels of nitric oxide and clinical and arthroscopic findings of synovitis or cartilaginous degeneration. Study design. Arthroscopic surgery was performed on 20 joints in 15 female patients with internal derangement and osteoarthritis of the temporomandibular joint. Synovial fluid aspirates were obtained immediately before arthroscopy. Synovial fluid was also obtained from 14 joints of 11 female asymptomatic volunteers. The concentration of nitrite in the fluid recovered from each temporomandibular joint was measured through use of a highly sensitive and specific chemiluminescence detection method, calibrated per 1 mg of synovial fluid protein and expressed as nitric oxide; the result was then compared with clinical and arthroscopic findings of synovitis and cartilaginous degeneration. Results. Significantly higher levels of nitric oxide (median, 0.331 uμmol/mg) were seen in the patients with internal derangement and osteoarthritis than in the control group (median, 0.001 μmol/mg; P < .0001). Synovial fluid from joints with pain in the joint area had significantly higher levels of nitric oxide than did fluid from joints without such pain. Synovial fluid from joints with degenerative changes (median, 0.467 μmol/mg) had significantly higher levels of nitric oxide than did fluid from joints without osteoarthritis (median, 0.057 μmol/mg; P < .05). Although the levels of nitric oxide in synovial fluid aspirates were markedly elevated in some joints with synovitis, there was no correlation between the levels of nitric oxide and the presence of synovitis. Conclusions. The findings indicate that increased levels of nitric oxide are involved in the pathogenesis of cartilaginous degeneration of the temporomandibular joint.
|Number of pages||8|
|Journal||Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics|
|Publication status||Published - 1999 Jan 1|
ASJC Scopus subject areas
- Oral Surgery