Assignment of the absolute configuration of goniodomin a by NMR spectroscopy and synthesis of model compounds

Yoshiyuki Takeda, Jinglu Shi, Masato Oikawa, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

The complete absolute configuration of goniodomin A, an actin-targeting polyether macrolide isolated from the marine dinoflagellate Alexandrium hiranoi, was established from analysis of ROESY experiments and coupling constants, synthesis of suitable model compounds for NMR spectroscopic comparisons, degradation experiments, and correlation with synthetic reference compounds.

Original languageEnglish
Pages (from-to)1013-1016
Number of pages4
JournalOrganic letters
Volume10
Issue number5
DOIs
Publication statusPublished - 2008 Mar 6

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Assignment of the absolute configuration of goniodomin a by NMR spectroscopy and synthesis of model compounds'. Together they form a unique fingerprint.

Cite this