Assessment of the thermal outcome during steam-pulse ablation for sheep tissue

Hitomi Anzai, Rolf Stämpfli, Adriano Wang-Leandro, Luciano F. Boesel, Shelley Kemp, Rene M. Rossi, Agnieszka A. Karol, Makoto Ohta, Henning Richter

Research output: Contribution to journalArticlepeer-review

Abstract

Thermal ablation has attracted attention as a minimally invasive tissue ablation treatment. Steam flow was recently introduced as a novel ablation procedure. This work aimed to assess the applicability of pulsated steam flow for tumor ablation. Ex vivo ablation was performed using liver, muscle, and fat tissues of sheep. Three experimental protocols of pulse number were administered to these tissues, while computational simulation was conducted according to the ex vivo tests for each tissue. Real-time measurements of temperature revealed heat propagation during and subsequent to ablation. The peak temperature was achieved after ablation. The time to reach the peak (highest temperature) increased with the distance from the thermal sensor to the steam needle according to thermal conductivity, except for steam leakage along to gap between the tissue and blood vessel. A cross-section of the ablated specimen clearly revealed the boundaries of cell defects. The ablated area was droplet shaped up to the steam needle. Computational simulations revealed that the ablated area was consistent with the area with the highest temperature. Though several limitations still remain such as no blood circulation, pulsated steam flow can ablate diverse animal tissues.

Original languageEnglish
Article number100966
JournalThermal Science and Engineering Progress
Volume25
DOIs
Publication statusPublished - 2021 Oct 1

Keywords

  • Computational simulation
  • Ex vivo test
  • Steam ablation
  • Thermal propagation

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes

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