Assessment of the perioperative factors contributing to the hemodynamic changes during surgery in ten patients with pheochromocytoma

Daisuke Konno, Ryo Nishino, Yutaka Ejima, Eiko Ohnishi, Kuniko Sato, Shin Kurosawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background : Intensive perioperative management is required for adrenalectomy in patients with pheocromocytoma because of the unstable hemodynamics and life threatening cardiovascular disturbances due to catecholamine surge from the neuroendocrine tumors. The aim of this study was to assess the perioperative factors contributing to the hemodynamic changes during surgery in pheochromocytoma. Methods : Ten patients with pheochromocytoma undergoing elective adrenalectomy were enrolled in this retrospective study. The circulating blood volume before surgery and the perioperative factors associated with hemodynamic changes during surgery were assessd by the pulse dye densitometry and Vigileo™/FroTrac™ system, respectively. Results : The decreases of blood pressure after resections of the central veins from tumors were significantly greater in laparotomy than those in laparoscopic surgery (P<0.05). In addition, the decreases of blood pressure after resection of the central were correlated with tumor sizes (R= -0.611), perioperative noradrenaline (NA) blood levels (R= -0.860), perioperative amounts of NA in urine (R=-0.743), and mean stroke volume variations for 5 min after resection of the veins(R= -0.679). Conclusions : The decreases of blood pressure after resections of the central veins are dependent on the perioperative blood NA levels, the level of NA in the perioperative urine testig, and tumor sizes.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalJapanese Journal of Anesthesiology
Volume62
Issue number4
Publication statusPublished - 2013 Apr

Keywords

  • Blood volume
  • Hemodynamics
  • Perioperative managements
  • Pheocromocytoma
  • Vigileo™/ FroTrac™

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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