Assessment of radiotherapeutic effects on experimental tumors using 18F-2-fluoro-2-deoxy-D-glucose

Yoshinao Abe, Taiju Matsuzawa, Takehiko Fujiwara, Hiroshi Fukuda, Masatoshi Itoh, Kenji Yamada, Keiichiro Yamaguchi, Tachio Sato, Tatsuo Ido

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Abstract

The purpose of this study is to evaluation the effect of tumor volume and radiotherapy on the uptake of 18F-2-fluoro-2-deoxy-D-glucose (18FDG). The tumor models used were mouse mammary carcinoma MM48, FM3A, and rat hepatoma AH109A. Results were expressed as an 18FDG uptake ratio. This was the ratio of irradiated tumor uptake of 18FDG to unirradiated tumor uptake. The total tumor uptake was expressed as 18FDG uptake ratio multiplied by relative tumor volume. Following 20 Gy irradiation of the radioresistant tumor (MM48), the 18FDG uptake ratio was found to be unchanged, whereas in radiosensitive tumors (FM3A) the 18FDG uptake ratio was 0.37, the relative tumor volume was 0.31, and the calculated total tumor uptake was 0.11 on the eighth day after irradiation. The total tumor uptake was lower than the relative tumor volume. AH109A began to regrow after ten Gy irradiation, accompanied by elevated uptake of 18FDG on the seventh day. These results suggest that the 18FDG uptake by tumor is a good marker of radiotherapeutic effects as well as relapses of cancers and is more sensitive than morphological methods.

Original languageEnglish
Pages (from-to)325-328
Number of pages4
JournalEuropean Journal of Nuclear Medicine
Volume12
Issue number7
DOIs
Publication statusPublished - 1986 Oct 1

Keywords

  • Assessment of radiotherapeutic effects
  • F-fluorodeoxyglucose
  • Tumor glucose uptake

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Abe, Y., Matsuzawa, T., Fujiwara, T., Fukuda, H., Itoh, M., Yamada, K., Yamaguchi, K., Sato, T., & Ido, T. (1986). Assessment of radiotherapeutic effects on experimental tumors using 18F-2-fluoro-2-deoxy-D-glucose. European Journal of Nuclear Medicine, 12(7), 325-328. https://doi.org/10.1007/BF00263812